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TranscriptomicsTranscription profiling of rat mammary gland, liver and lung tissues treated with targretin, 9-cis retinoic acid, or 4-hydroxyphenylretinamide
A rexinoid, targretin (TRG) and two retinoids, 9-cis retinoic acid (9cRA) and 4-hydroxyphenylretinamide (4HPR) were examined for their effects on gene expression in rat mammary gland, liver, and lung tissues. The chemopreventive effects of these agents have largely been attributed to their ability t...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3952 | biostudies-arrayexpress
TranscriptomicsNitric Oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance
JS-K, a NO donor which capable to induce cancer apopotosis, it's killing mechanism was investigated in this study. We found out that JS-K induce apopotosis via deregulating the GSH/GSSG redox couple. Leukemia cells were treated with JS-K and then assayed for metabolic changes by LC/MS and gene expre...
ORGANISM(S): Homo sapiens 
2012-11-17 | E-GEOD-42344 | biostudies-arrayexpress
TranscriptomicsGenetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis
Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-63912 | biostudies-arrayexpress
TranscriptomicsIdentification of promoter sequence elements involved in specific recognition by the ?S subunit of bacterial RNA polymerase.
Promoter recognition by bacterial RNA polymerase is mediated by ? subunits, which assemble transiently to RNA polymerase core enzyme (E) during transcription initiation. ? subunits drive transcription of specific sets of genes by allowing RNA polymerase to interact with different promoter sequences....
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-05-31 | E-GEOD-22207 | biostudies-arrayexpress
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