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ProteomicsSilencing of double stranded RNA sensing is required for early embryonic development
The type I interferon (IFN) response is inactive during early mammalian development and becomes functional only after gastrulation. As a result, the totipotent and pluripotent embryonic stages remain susceptible to pathogens, including viruses. Here, we demonstrate that pluripotent mouse embryonic s...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-26 | PXD059977 | Pride
Chromatin-associated proteomics  mda5  pluripotency stem cells 
ProteomicsControl of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune responses. Here, we show that inactivation of the double stranded RNA (dsRNA)-binding protein DGCR8 unleas...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD074388 | Pride
Interferon response Transposable elements 22qds Human Dsrna Dgcr8 Stem cells Mouse Pa-1 
TranscriptomicsDGCR8 HITS-CLIP reveals novel functions for the Microprocessor (CLIP-seq)
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. We have used high-throughput sequencing of RNAs isolated by crosslinking immuno...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39086 | biostudies-arrayexpress
ProteomicsDICER1 syndrome-associated mutations lead to 3p-miRNA gain of function and increased metastatic potential
The DICER1 gene is mutated in cancer, including Dicer1 syndrome, a rare tumour predisposition syndrome. Cancer-associated hotspots mutations have been reported in both catalytic domains of Dicer, and are predicted to disrupt miRNA processing activity. To understand these hotspot mutations in cancer ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD072167 | Pride
Cancer Dia Dicer1 Mutations Exploris480 
TranscriptomicsHigh-resolution, genome-wide analysis of human medulloblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Medulloblastoma (MB) is the most common pediatric brain tumor and is an aggressive neoplasia arising in the cerebellum. MB includes four major histological subsets commonly subdivided in: classic, desmoplastic, anaplastic or large-cell, and nodular. The current patients risk stratification is based ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-23005 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 grou...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-25771 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patientsM-bM-^@M-^Y relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 12...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-35953 | biostudies-arrayexpress
TranscriptomicsA genotype-first approach for the molecular and clinical characterization of uncommon de novo microdeletion of 20q13.33
Molecular cytogenetic techniques such as microarray analysis have allowed for a “genotype-first” approach to the characterization of chromosome abnormalities: in the absence of clinical features suggestive of a specific syndrome, patients with similar copy number imbalances can be examined for commo...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21536 | biostudies-arrayexpress
TranscriptomicsThe mutation spectrum revealed by paired genome sequences from a lung cancer patient
This SuperSeries is composed of the following subset Series: GSE20574: Agilent 244A aCGH array for comparison of lung tumor CNA to high-throughput sequencing data GSE20578: Assessment of mutation on expression levels GSE20584: Affymetrix SNP6.0 array for comparison of lung tumor and adjacent normal ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20585 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Atm-/-,mTerc-/-,p53-/- triple knock-out lymphoma vs normal
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7607 | biostudies-arrayexpress
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