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TranscriptomicsRotenone susceptibility phenotype in olfactory derived patient cells as a model of idiopathic Parkinson’s disease
Physiologically relevant cellular models are critical for understanding complex pathological processes. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by motor and non-motor symptoms. Several cellular models for PD have been developed to reproduce the a...
ORGANISM(S): Homo sapiens 
2016-10-04 | E-MTAB-4164 | biostudies-arrayexpress
TranscriptomicsA patient-derived neural stem cell model for hereditary spastic paraplegia
Hereditary Spastic Paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPG4 are a major cause of autosomal-dominant HSP. Spastin, the protein encoded by SPG4, is a microtubule-severing protein and is enriched in the distal axon of cor...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-TABM-1180 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of fibroblasts from eight individuals to evaluate variability in the establishment of induced pluripotent stem cell lines and to develop future cellular models of disease.
Fibroblasts from eight individuals were chosen to evaluate variability in the establishment of iPSC lines and to develop future cellular models of disease. From the eight patients four were healthy controls (Cont) and four were schizophrenic (Sz). All the patients were males with ages ranging from 2...
ORGANISM(S): Homo sapiens 
2012-09-29 | E-MTAB-1040 | biostudies-arrayexpress
UnknownHereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery.
Not available
S-EPMC8004882 | biostudies-literature
UnknownDirectional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.
Not available
S-EPMC8430705 | biostudies-literature
ProteomicsAntibody-free targeted proteomics assay for absolute measurement of α-tubulin acetylation
Acetylation of α-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities. Dysregulated microtubule dynamics characterised by differential α-tubulin acetylation is a hallmark of cancer, neurodegeneration and other complex...
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-07-30 | PXD018626 | panorama
TranscriptomicsTranscription profiling of neurosphere-derived cell lines from patients with brain disorders
Understanding the molecular bases of neurological and psychiatric conditions is hampered by a lack of suitable patient-derived cellular models. The olfactory mucosa is a continually regenerating neural tissue that contains multipotent neural stem cells which are accessible and expandable in vitro as...
ORGANISM(S): Homo sapiens 
2010-06-04 | E-TABM-724 | biostudies-arrayexpress
UnknownA cross-study transcriptional analysis of Parkinson's disease.
Not available
S-EPMC2654916 | biostudies-literature
TranscriptomicsDNA methylation in schizophrenia in different patient-derived cell types
DNA methylation of gene promoter regions represses transcription and is a mechanism via which environmental risk factors could affect cells during development in individuals at risk for schizophrenia. We investigated DNA methylation in patient-derived cells that might shed light on early development...
ORGANISM(S): Homo sapiens 
2017-11-01 | E-MTAB-5016 | biostudies-arrayexpress
UnknownOxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons.
Not available
S-EPMC7221066 | biostudies-literature
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