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MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
TranscriptomicsMacrophage Microvesicles Induce Macrophage Differentiation and miR-223 Transfer
Microvesicles (MV) are small membrane-bound particles comprised of exosomes and various sized extracellular vesicles. These are released by a number of cell types. Microvesicles have a variety of cellular functions from communication to mediating growth and differentiation. Microvesicles contain pro...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41889 | biostudies-arrayexpress
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes to macrophage differentiation
Macrophages play a critical role in the pathogenesis of many diseases, including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Monocytes recruited into tissues from peripheral blood differentiate into macrophages. There is limited data concerning the global changes in the e...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-8286 | biostudies-arrayexpress
ProteomicsProteomic and morphologic characterization of ovine macrophage differentiation and polarization - secretomes
Macrophages play crucial roles in inflammation and tissue homeostasis, exhibiting phenotypic and functional plasticity that enables them to initiate, sustain, or resolve inflammation. To support the evidence-based selection of biomedically relevant preclinical models, this study comprehensively char...
ORGANISM(S): Ovis aries 
2026-01-12 | PXD068541 | Pride
Proteomics Macrophage differentiation Tissue repair Inflammation Sheep 
ProteomicsProteomic and morphologic characterization of ovine macrophage differentiation and polarization – cell lysates
Macrophages play crucial roles in inflammation and tissue homeostasis, exhibiting phenotypic and functional plasticity that enables them to initiate, sustain, or resolve inflammation. To support the evidence-based selection of biomedically relevant preclinical models, this study comprehensively char...
ORGANISM(S): Ovis aries 
2026-01-12 | PXD069059 | Pride
Proteomics Macrophage differentiation Tissue repair Inflammation Sheep 
ProteomicsSelective phospohorylation of macrophage differentiation
The differentiation of macrophages from monocytes is a tightly controlled and complex biological process. Although numerous studies have been conducted using biochemical approaches or global gene/protein profiling, the mechanisms of the early stages of differentiation remain unclear. Here we used TH...
ORGANISM(S): Homo sapiens (Human) 
2015-09-02 | PXD002496 | Pride
Macrophage differentiation Phosphoproteome 
TranscriptomicsSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of ...
ORGANISM(S): Homo sapiens 
2013-10-16 | E-GEOD-40131 | biostudies-arrayexpress
MetabolomicsSpirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate
Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirul...
2026-06-30 | MTBLS14903 | MetaboLights
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