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ProteomicsMps1(Mph1) Kinase phosphorylates Mad3 to Inhibit Cdc20Slp1 –APC/C and maintain spindle checkpoint arrests
The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mads/BubR1 is a key component of the mitotic chec...
ORGANISM(S): Schizosaccharomyces pombe 
2016-03-31 | PXD003806 | Pride
Mad3 Kinase Mitosis Spindle Phosphorylation S.pombe 
UnknownThe spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).
Not available
S-EPMC2516979 | biostudies-literature
UnknownA novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation.
Not available
S-EPMC2169189 | biostudies-literature
UnknownMad2 and Mad3 cooperate to arrest budding yeast in mitosis.
Not available
S-EPMC3277655 | biostudies-literature
UnknownMps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.
Not available
S-EPMC4755545 | biostudies-literature
UnknownMad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Not available
S-EPMC2877644 | biostudies-literature
UnknownThe Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.
Not available
S-EPMC6657678 | biostudies-literature
UnknownKinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.
Not available
S-EPMC3315010 | biostudies-literature
UnknownThe Arabidopsis BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling.
Not available
S-EPMC10963012 | biostudies-literature
UnknownMad3 modulates the G1 Cdk and acts as a timer in the Start network.
Not available
S-EPMC9075807 | biostudies-literature
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