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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
UnknownComplete Genome of Bacillus pumilus Siphophage Glittering.
Not available
S-EPMC3853048 | biostudies-literature
TranscriptomicsMicroarray study of the Sex Inducer Proteins in Cryptococcus neoformans var. neoformans (JEC20/21)
To identify genes regulated by the homeodomain transcription factors Sxi1M-NM-1 and Sxi2a (Sex Inducer 1M-NM-1 and 2a) in Cryptococcus neoformans, we carried out a whole-genome expression experiment. We performed two independent whole-genome microarray experiments comparing transcript levels in cell...
ORGANISM(S): Cryptococcus neoformans var. neoformans 
2014-07-01 | E-GEOD-57287 | biostudies-arrayexpress
TranscriptomicsBernardo mesoderm differentiation
Transcriptional profiling of hESCs in chemically-defined culture media compared to hESCs differentiated for 36h in the additional presence of FGF, LY294002 and either BMP or ActivinA.
ORGANISM(S): Homo sapiens 
2011-08-24 | E-MTAB-464 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and QTL mapping of 60 mice from an F2 sample segregating for diabetes to generate expression trait correlations and expression quantitative trait locus mapping.
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. To map gene regulatory pathways, we used microarray-derived gene expression measurements in 60 individuals of an F2 sample segregat...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3330 | biostudies-arrayexpress
TranscriptomicsGene expression patterns in Schistosoma mansoni larvae and eggs
Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts. The infective schistosome cercaria develops from an undifferentiated germ ball within the daughter sporocyst in the molluscan host, during which considerable morphological develo...
ORGANISM(S): Schistosoma mansoni 
2010-05-29 | E-GEOD-22037 | biostudies-arrayexpress
TranscriptomicsAnalysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation
Artificial transcription factors (ATFs) and genomic nucleases based on a DNA binding platform consist- ing of multiple zinc finger domains are currently be- ing developed for clinical applications. However, no genome-wide investigations into their binding speci- ficity have been performed. We have c...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-59980 | biostudies-arrayexpress
TranscriptomicsA database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti
Investigation of whole genome gene expression level changes during a 44 hour time period in Aedes aegypti observed under light/dark and constant dark conditions. This is a 12-plex high defination NimbleGen array design. The Higgs White Eye (Wh) strain of Aedes aegypti was investigated for rhythmic e...
ORGANISM(S): Aedes aegypti 
2014-08-19 | E-GEOD-60496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cells and their differentiated progeny grown in chemically defined conditions
Comparison of H9 human embryonic stem cells, grown in chemically defined and animal-product free conditions, with their differentiated progeny - mesendodermal progenitors arisen as the result of changes made to chemically defined hESC growth conditions. Contributes to a larger work on the use of che...
ORGANISM(S): Homo sapiens 
2009-07-31 | E-MEXP-930 | biostudies-arrayexpress
TranscriptomicsVallier 3day endoderm
Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-MTAB-467 | biostudies-arrayexpress
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