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TranscriptomicsUBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency,...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-59376 | biostudies-arrayexpress
ProteomicsK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Conjugation of ubiquitin (Ub) to numerous substrate proteins regulates virtually all cellular processes. Eight distinct ubiquitin polymer linkages specifying different functional outcomes are generated in cells. However, the roles of some atypical poly-ubiquitin topologies, in particular linkages vi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD023579 | Pride
Ubiquitin Proteomics K27 
ProteomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome maintenance
We applied a cell-based Ub replacement strategy enabling specific, conditional abrogation of each of the seven lysine-based Ub chain types in human cells to comprehensively profile global ubiquitylation changes resulting from disabling formation of individual Ub chain types. Focusing on K29-linked u...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD056295 | Pride
Human Ubiquitylation Ptm 
ProteomicsGain-of-function mutations amplify cytotoxic FAM111 protease activity in poikiloderma, gracile bone dysplasia and Kenny-Caffey syndromes
Dominant missense mutations in the human serine protease FAM111A underlie perinatally lethal gracile bone dysplasia and Kenny-Caffey syndrome 1-3, yet how FAM111A mutations lead to disease is not known. We show that FAM111A proteolytic activity suppresses DNA replication and transcription by displac...
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD017978 | Pride
Kenny-caffey syndromes Fam111 Genetic disorder Poikiloderma Proteases Replication stress Transcrition 
UnknownMultisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites.
Not available
S-EPMC7307195 | biostudies-literature
UnknownRNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
Not available
S-EPMC3678163 | biostudies-literature
UnknownQuantitative hypermorphic FAM111A alleles cause autosomal recessive Kenny-Caffey syndrome type 2 and osteocraniostenosis.
Not available
S-EPMC11949059 | biostudies-literature
UnknownEvolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance.
Not available
S-EPMC7762937 | biostudies-literature
ProteomicsAnalysis of histone PTMs in nascent chromatin in new and old histones upon DNA damage (CAL353, CAL358) using the NCC-SILAC approach
Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are assumed to have a causal role in establishing distinct chromatin structures. However, it remains unknown how specific histone PTMs are regulated at brok...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD018220 | Pride
Ncc Histone ptms Silac Camptothecin Replication 
UnknownCONSERVATION. Genetic assignment of large seizures of elephant ivory reveals Africa's major poaching hotspots.
Not available
S-EPMC5535781 | biostudies-literature
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