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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
TranscriptomicsmiR-223 in esophageal adenocarcinoma carcinogenesis
miR-223 is step-wise increasingly up-regulated in the normal esophagus - Barrett's esophagus -esophageal adenocarcinoma carcinoma sequence. In this study, we aimed to determine the function of miR-223 in esophageal adenocarcinoma carcinogenesis. miR-223 was transfected in OE33 cells using 10nM pre-m...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44120 | biostudies-arrayexpress
UnknownGemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial.
Not available
S-EPMC3565012 | biostudies-literature
TranscriptomicsGene expression data ARID1A knockdown OE33 cells versus mock OE33 cells
A nonsense mutation in ARID1A was identified by next generation sequencing in non-dysplastic Barrett's esophagus [BE] tissue and esophageal adenocarcinoma [EAC] tissue of a patient diagnosed with EAC. Immunohistochemistry performed on an independent archival cohort demonstrated ARID1A protein loss i...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38380 | biostudies-arrayexpress
TranscriptomicsThe gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
Pancreatic ductal adenocarcinoma (PDAC) is a nearly uniformly lethal malignancy, with most patients facing an adverse clinical outcome. Given the pivotal role of aberrant Notch signaling in the initiation and progression of PDAC, we investigated the effect of MRK-003, a potent and selective γ-secre...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37645 | biostudies-arrayexpress
ProteomicsAn Allele Agnostic Mutant KRAS Inhibitor Demonstrates Broad Spectrum Tumour Growth Inhibition in Pancreatic Ductal Adenocarcinoma
The KRAS oncogene triggers complex phosphorylation cascades, including canonical pathways such as RAF/MEK/ERK, PI3K/AKT, and RALGDS/RAL, and their engagement varies depending on the cancer context. Integration of transcriptomic, proteomic, and phosphoproteomic analysis of KRAS mutant cancers has bee...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD051337 | Pride
Kpc Pankrasi Kras Proteomic Phospoproteomic Pdac 
UnknownThe gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-37645 | biostudies-other
TranscriptomicsTranscription profiling of human colon biopsies obtained from patients with ulcerative colitis, Chrohn's disease vs. normal to identify pathogenic processes underlying these disease subtypes
Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies. To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies to estabolish 36 expression pr...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-6731 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer cell line HCT116 expressing miR-43a vs. controls to investigate miR-43a induced gene expression
In order to examine the consequences of human miR-34a induction on the transcriptome, HCT116 cells (a colon cancer cell line) were infected with a retrovirus that produces miR-34a. Gene expression profiles were then monitored using Affymetrix microarrays. Affymetrix microarrays were used to examine...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7754 | biostudies-arrayexpress
Proteomics,MultiomicsA draft map of the human proteome
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fouri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-16 | MSV000079514 | MassIVE
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