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TranscriptomicsMolecular signatures of peripheral blood mononuclear cells following chronic IFN-alpha: Relationship of OAS2 with Depression and Fatigue
Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-31187 | biostudies-arrayexpress
UnknownThe bii4africa dataset of faunal and floral population intactness estimates across Africa's major land uses.
Not available
S-EPMC10861571 | biostudies-literature
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampus and retina from two rare inbred mouse models of accelerated neurological senescence ( SAMP8 and SAMP10) and a related wild type strain SAMR1 to study molecular senescence of the retina and hippocampus.
Background: Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senesce...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6238 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the transcriptome differences between the two major subtypes of diffuse large B cell lymphoma (DLBCL). DLBCL is the most common form of non-Hodgkin’s lymphoma and has two major subtypes: germinal center B-cell-like (GCB) and activated B-cell-like (ABC). When c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50721 | biostudies-arrayexpress
TranscriptomicsAntenatal Blood DNA Methylation Profiles
DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and would not develop depression post partum. We recruited 54 pregnant women with a history of either Major Depression or Bipo...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-44132 | biostudies-arrayexpress
ProteomicsProteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy Proteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy
Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs) after a cardiac ischemic episode. Drugs in the class of the glucagon-like peptide-1 receptor agonists (GLP1Ra) have demonstrated benefits for he...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD027867 | Pride
Mitochondrion  cellular respiration  metabolism Proteomics  glucagon-like peptide-1 receptor agonists  dmb  early cardiac remodeling 
TranscriptomicsHigh throughput sequencing of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain repertoires
We used 454 sequencing to assess the repertoire of B cell subsets from bone marrow, spleen, and small intestinal lamina propria from two mouse strains. We used a RAG2-GFP reporter mouse strain (129Sve background) to isolate CD19+ RAG2+ B lineage cells from bone marrow and small intestinal lamina pro...
ORGANISM(S): Mus musculus 
2013-07-16 | E-GEOD-48870 | biostudies-arrayexpress
ProteomicsComplexome Profiling of the mitochondrial proteome from Viscum album
Recent genomic studies revealed that mitochondria from mistletoe species appear to lack a major amount of genes, indicating a possible loss of the NADH ubiquinone oxidoreductase (complex I) which forms an essential part of the mitochondrial Oxidative Phosphorylation System (OXPHOS). This dataset is ...
ORGANISM(S): Viscum album 
2018-04-23 | PXD008974 | Pride
Mitochondria Mistletoe Proteome Lc-msms Blue native Viscum album 
GenomicsWhole genome mapping of STAT3 binding sites in the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the effect of the transcription factor STAT3 in the two major subtypes of diffuse large B cell lymphoma (DLBCL). STAT3 is a signal transducer that, when dysregulated, becomes a powerful oncogene found in many human cancers, including DLBCL. DLBCL is the most c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50723 | biostudies-arrayexpress
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