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MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
ModelsGérard - 2019 - Coupling the cell cycle and the cell transformation networks (SBML)
Model for the Let-7-mediated coupling between the CDK network driving the cell cycle and the malignant cell transformation network. The model is based on the cell cycle model by Gérard and Goldbeter (Interface Focus 1, 24-35, 2011) and on a model for the epigenetic switch linking inflammation to cel...
2019-07-02 | MODEL1906070001 | BioModels
GenomicsX-irradiation and malignant transformation
Genomic and transccriptomic landscape of two step malignant transformation process.
PRJEB37468 | ENA
GenomicsGene expression changes associated with malignant transformation of oral potentially malignant disorders
Gene expression changes associated with malignant transformation of oral potentially malignant disorders
PRJNA657049 | ENA
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [copy number variation]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-61650 | biostudies-arrayexpress
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [gene expression]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-61597 | biostudies-arrayexpress
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