Sort   by:  
 Page size 
ProteomicsFOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration
FOXK2 is a crucial transcription factor implicated in a wide array of biological activities and yet understanding of its molecular regulation at the level of protein turnover is limited. Here we identify that FOXK2 is sensitive to degradation by the virulent pathogens P. aeruginosa and K. pneumoniae...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050221 | Pride
Pulldown Foxk2 Lc-ms/ms 
ProteomicsTargeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses in bacterial pneumonia
The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. Here We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacterial pneumonia in humans and displays intrinsic innate...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050224 | Pride
Inflammation Pneumonia Dars2 
ProteomicsA Fbxo48 inhibitor prevents pAMPKa degradation and ameliorates insulin resistance
Beas-2b cells treated with vehicle or BC1618 compound, which targets the ubiquitin E3 ligase for targeted degradation of pAMPKa protein. Cell lysate was subjected to mass spectrometry for phosphoproteomics to uncover alterations in the phosphoproteome.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-20 | MSV000086334 | MassIVE
Sort   by:  
 Page size