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ProteomicsPlasmid manipulation of bacterial behaviour through translational regulatory crosstalk
pQBR103 is a naturally occurring plasmid known to alter the behaviour of its host, Pseudomonas fluorescens. This plasmid encodes a predicted translational regulator, rsmQ which is a homologue of known global regulators within Pseudomonas. Within this study we compared Pseudomonas fluorescens SBW25 p...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) Bacteria 
2023-01-13 | PXD033640 | Pride
Tmt Rnaseq Translational regulator Pseudomonas fluorescens sbw25 Quantitative proteomics Plasmid 
ProteomicsBatR: A novel regulator of antibiotic tolerance in P. aeruginosa biofilms
Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen. Chronic infections are associated with biofilms, conferring resistance to antimicrobial agents and complicating treatment strategies. This study focuses on understanding the role of the uncharacterized gene PA3049, upregul...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-06-26 | PXD050995 | Pride
Proteomics Pseudomonas aeruginosa Antibiotic tolerance Biofilms 
ProteomicsBatR: A novel regulator of antibiotic tolerance in P. aeruginosa biofilms
Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen. Chronic infections are associated with biofilms, conferring resistance to antimicrobial agents and complicating treatment strategies. This study focuses on understanding the role of the uncharacterized gene PA3049, upregul...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-06-26 | PXD050997 | Pride
Proteomics Pseudomonas aeruginosa Antibiotic tolerance Biofilms 
ProteomicsAn integrative, multi-omics analysis of the Hfq regulon
The ability of bacteria to respond to environmental change is based on the exploration of sophisticated regulatory landscapes. While we can learn a great deal from reductive analyses of individual pathways, and global approaches to gene regulation, a deeper understanding of these complex signalling ...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2017-10-18 | PXD005621 | Pride
Hfq Pseudomonas fluorescens Posttranscriptional regulation Multi-omics Proteomics Isobaric labelling 
ProteomicsBatR: A novel regulator of sub-inhibitory antibiotic tolerance in Pseudomonas aeruginosa biofilms
Pseudomonas aeruginosa is a multidrug-resistant opportunistic pathogen, with chronic infections often associated with biofilms that enhance antibiotic resistance. This study investigates the uncharacterized gene PA3049, which is upregulated under biofilm conditions, to determine its role in infectio...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-06-26 | PXD062857 | Pride
Pseudomonas aeruginosa  biofilms  antibiotic resistance  proteomics 
ProteomicsSecond messenger control of mRNA translation by dynamic ribosome modification
Pseudomonas species employ complex, dynamic signalling networks to fine-tune responses to changing environments, with regulation taking place at the transcriptional, post-transcriptional and post-translational levels. Control of mRNA translation and hence protein abundance is a crucial element of th...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2020-06-30 | PXD017233 | Pride
Signalling Pseudomonas Ribosomal proteins Cyclic-di-gmp Itraq proteome 
GenomicsRole of RccR in the transcriptional control of primary carbon metabolism in Pseudomonas
To characterise the RccR regulon, we performed a ChIP-seq assay using a polyclonal RccR antiserum on SBW25 WT/rccR strains grown in minimal pyruvate and glycerol media. We were able to identify 8 RccR binding sites from this experiment including one in the rccR promoter region itself. The peaks iden...
ORGANISM(S): Pseudomonas fluorescens 
2017-08-24 | E-MTAB-5745 | biostudies-arrayexpress
ProteomicsGlobal control of bacterial translation by a specific ribosomal modification
Translational regulation plays a critical role in controlling the environmental responses of diverse bacterial species. In addition to existing, well-established regulatory pathways, the alteration of ribosome function by specific posttranslational modification represents a potential further mechani...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD001376 | Pride
Pseudomonas Translational regulation Ribosome Rhizosphere 
ProteomicsGlobal control of bacterial translation by a specific ribosomal modification
Translational regulation plays a critical role in controlling the environmental responses of diverse bacterial species. In addition to existing, well-established regulatory pathways, the alteration of ribosome function by specific posttranslational modification represents a potential further mechani...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD001371 | Pride
Pseudomonas Translational regulation Ribosome Rhizosphere 
ProteomicsTranslational regulation via ribosome modification
This dataset compares the proteomes of WT P. fluorescens and a delta-hfq mutant strain. This forms part of our characterisation of a new mechanism for translational control in bacteria, based on the covalent modification of a ribosomal protein by the enzyme RimK. RimK modification induces specific e...
ORGANISM(S): Pseudomonas fluorescens (strain SBW25) 
2016-02-17 | PXD002573 | Pride
Pseudomonas Translational control Ribosomal modification Lc-ms/ms 
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