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ProteomicsThe long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein
The roles of long noncoding RNAs (lncRNAs) in synaptic transmission and neuronal development are emerging. Here we applied an integrated bioinformatic/biological screening strategy to identify lncRNAs that regulate synaptic vesicle release. We identified neuroLNC, a conserved neuron-specific nuclear...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD013434 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
ProteomicsPrecisely measured protein lifetimes in the mouse
The turnover of brain proteins is critical for organism survival, and its perturbations are strongly linked to pathology. Nevertheless, precise protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically-labeled amino acids, followed...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD010859 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
UnknownDifferences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons.
Not available
S-EPMC8405817 | biostudies-literature
UnknownProtein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
Not available
S-EPMC9122331 | biostudies-literature
UnknownThe long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
Not available
S-EPMC6920028 | biostudies-literature
UnknownThe codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
Not available
S-EPMC6237891 | biostudies-literature
UnknownBCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
Not available
S-EPMC7116798 | biostudies-literature
ProteomicsPrecisely measured protein lifetimes in the brain of aged mice
Aging, which is associated with protein homeostasis defects, is one of the most prominent risk factors for neurodegenerative disorders and the regulation of protein homeostasis is essential for brain health. While several studies have addressed changes in protein abundance due to aging, little is kn...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD023994 | Pride
Synapse Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes 
UnknownPrecisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
Not available
S-EPMC6185916 | biostudies-literature
UnknownInhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
Not available
S-EPMC6331730 | biostudies-literature
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