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TranscriptomicsIdentification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis
Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during embryonic development. Rcor1 mutant proerythroblasts, unlike normal cells, can form myeloid colonies in...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50708 | biostudies-arrayexpress
TranscriptomicsPolycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression. RNA-seq was ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-59442 | biostudies-arrayexpress
ProteomicsC-terminal Domain Small Phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
The RE1 Silencing Transcription Factor (REST) in stem cells represses hundreds of genes essential to neuronal function. During neurogenesis, REST is degraded in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype. Prior studies indicate that part of the degradation ...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-09-15 | PXD001127 | Pride
Erk Pin1 Neuronal differentiation. Re1 silencing transcription factor Btrcp Ctdsp1 Rest 
GenomicsPolycomb Repressor Complex 2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results showed that a majority of REST-bound genomic regions were not associated with H3K27me3 enrichment and loss of H3K27me3 enrichment was not a g...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-48320 | biostudies-arrayexpress
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