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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
TranscriptomicsMntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.
Transcriptional profiling of SirR and manganese regulated expression of genes in Mycobacterium tuberculosis strains comparing high manganese vs. low manganese in Rv (wild type Mycobacterium tuberculosis) and ST70 (mntR mutant strain of Mycobacterium tuberculosis) Two strains each with two conditions...
ORGANISM(S): Mycobacterium tuberculosis 
2015-12-08 | E-GEOD-70812 | biostudies-arrayexpress
ProteomicsProteomic Analysis on the Mechanism of Iron-Compensation Substitute for Manganese Deficiency of Streptococcus pneumoniae
Iron (Fe) and Manganese (Mn) are essential for bacterial survival and virulence as they are involved in catalysis, infection and biofilm formation. The basal metabolism of pathogenic bacteria would be disturbed by the deficiency of metal ions in the host environment. In this study, we found that Str...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2023-09-30 | PXD008652 | Pride
Manganese deficiency Iron-compensation Proteomic Streptococcus pneumoniae 
ProteomicsIntestinal response to dietary manganese depletion in Drosophila
Manganese is considered essential for animal growth. Manganese ions serve as cofactors to three mitochondrial enzymes: superoxide dismutase (Sod2), arginase and glutamine synthase. In Drosophila melanogaster, manganese has also been implicated in the formation of ceramide phosphoethanolamine, the in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-02-24 | PXD015543 | Pride
Superoxide dismutase (sod2) White + (w+) 
ProteomicsStudy physiological and biochemical response of Phaeocystis antarctica to different irradiance and manganese/ iron deficiency
Iron and light are typically recognized as major limiting factors controlling phytoplankton growth in the Southern Ocean. Recent field-based evidence suggests, however, that manganese concentrations in this region can be low enough to impact phytoplankton physiology and primary productivity. Our stu...
ORGANISM(S): Phaeocystis antarctica 
2019-06-25 | PXD010974 | Pride
Manganese Photosynthesis Deprivation Phaeocystis antarctica Proteomic Iron 
ProteomicsSystems-wide analysis of manganese deficiency-induced changes in gene activity of Arabidopsis roots
In this study, we undertook a comprehensive quantitative proteomic profiling of Arabidopsis roots from plants grown on Mn-deplete media, aiming at dissecting and cataloging the responses of Arabidopsis roots to Mn deficiency. We used LC-Q Exactive Orbitrap mass spectrometer to compile a near complet...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-10-26 | PXD003309 | Pride
Proteomics Manganese deficiency Systems biology Transcriptomics Post-transcriptional regulation 
UnknownIntestinal ZIP8 Regulates Tissue Manganese Distribution and Modifies Manganese Overload in ZIP14 Deficiency.
Not available
S-EPMC12698256 | biostudies-literature
UnknownHepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.
Not available
S-EPMC11141921 | biostudies-literature
UnknownSLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation.
Not available
S-EPMC4678430 | biostudies-literature
UnknownManganese-driven CoQ deficiency.
Not available
S-EPMC9563070 | biostudies-literature
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