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Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin chain architectures guide the binding events and itineraries of modified substrates. Various combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide bonds between the C-terminu...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD021286 | Pride
The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sens...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034517 | Pride
Artificial intelligence (AI) applications in biomedical settings face challenges such as data privacy and regulatory compliance. Federated Deep Learning (FDL) effectively addresses these issues. We developed ProCanFDL, where local models were trained on simulated sites using proteomic data drawn fro...
ORGANISM(S): Homo sapiens (Human) 
2025-05-29 | PXD056810 | Pride
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