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MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
ProteomicsIdentification of sites of ubiquitination in human UBQLN2
Using immunoprecipitations from HEK293T cells of UBQLN2-HA constructs, sites of ubiquitination were identified. A variety of UBQLN2 variants were studied including lysineless proteins, deletions of the UBL domain and N-terminal fusions to ubiquitin.
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD059465 | Pride
Ubiquilin ubiquitin ubqln2 ubl 
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
ProteomicsThe Drosophila acetyltransferase chameau (chm) promotes starvation resilience at the expense of a shortened life span
Proteins involved in cellular metabolism and molecular regulation have been shown to extend lifespan in various laboratory organisms. However, for any improvement in aging to confer an evolutionary benefit, organisms must also be able to survive under non-ideal conditions. Earlier, we discovered tha...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-05 | PXD042471 | Pride
Chameau Acetylation Starvation Hbo1 Drosophila 
UnknownSafe and transparent introduction and evaluation of targeted axillary dissection in patients with node-positive breast cancer undergoing primary surgery: international consensus process.
Not available
S-EPMC12574671 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownLongitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
Not available
S-EPMC7987018 | biostudies-literature
UnknownType I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Not available
S-EPMC8601717 | biostudies-literature
UnknownRespiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants.
Not available
S-EPMC7299433 | biostudies-literature
UnknownExpression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Not available
S-EPMC7335429 | biostudies-literature
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