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TranscriptomicsmiRNA expression in fast and slow skeletal muscle of wild type and SOD1-G93A mice
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. In a mouse model of ALS that expresses mutated human superoxide dismutase 1 (SOD1-G93A) skeletal muscle is one of the tissues affected early by m...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55507 | biostudies-arrayexpress
ProteomicsChromatin cell cycle proteomics reveals nuclear metabolism
The progression of the cell cycle is regulated by the expression of specific genes and fluctuations in cellular metabolic states. By conducting cell cycle-based transcriptomics, proteomics, and metabolomics analyses, previous research has identified cell cycle-dependent alterations at the molecular,...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055357 | Pride
Metabolism Cell cycle Chromatin Enzymes 
ProteomicsComprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells
we have performed a subcellular fractionation protocol, which enriches the chromatin-bound proteins across a panel of tissue types, both for cancerous and untransformed cells. Indeed we identify both metabolic enzymes which are consistently moonlighting on chromatin, while others are tissue and canc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-13 | PXD047504 | Pride
Chromatome  cancer  chromatin 
ProteomicsMitochondrial fuels ATP in the nucleus to prevent cell cycle arrest during mechanical confinement
Abstract The physical microenvironment regulates cell behaviour during tissue development and disease. Whether mechanical stress and physical space constraints reshape the subcellular localization of organelles and proteins resulting in functional adaptations is, however, unknown. Here, we performed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD043524 | Pride
Confinement Nuclear atp Mitochondria Cell cycle Nucleus Dna damage 
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