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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownHighly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.
Not available
S-EPMC6831736 | biostudies-literature
UnknownChemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold.
Not available
S-EPMC5725544 | biostudies-literature
UnknownNon-invasive modelling and parametric methods for quantification of MAO-B activity using [<sup>11</sup>C]L-deprenyl-D2 PET.
Not available
S-EPMC12812065 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
ProteomicsTranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping
Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylc...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD018580 | Pride
Human Abpp Lc-ms/ms 
ProteomicsGlobal mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line
Mucin-type-O-glycosylation on proteins is integrally involved in human health and disease and is coordinated by an enzyme family of 20 N-acetylgalactosaminyltransferases (GalNAc-Ts). Detailed knowledge on the biological effects of site-specific O-glycosylation is limited due to lack of information o...
ORGANISM(S): Homo sapiens (Human) 
2022-10-22 | PXD036791 | Pride
Galnt   fibronectin  ldlr  lrp  col17a1 Differential glycoproteomics. Crispr 3d tissue models  oragnoid 
TranscriptomicsCPD-seq mapping of UV damage formation and repair in yeast
UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. We have used a novel high-throughput sequencing method to precisely map UV-induced cyclobutane pyrimidine dimers (CPD...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-19 | E-GEOD-79977 | biostudies-arrayexpress
UnknownThe effects of gait training using powered lower limb exoskeleton robot on individuals with complete spinal cord injury.
Not available
S-EPMC5838988 | biostudies-literature
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
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