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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsEffects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells
Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibito...
ORGANISM(S): Homo sapiens 
2010-07-17 | E-GEOD-17167 | biostudies-arrayexpress
TranscriptomicsThe effects of moderate weight gain in adipose tissue gene expression in metabolically-normal (MNO) and metabolically-abnormal (MAO) subjects
Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. We tested the hypothesis that MNO, but not MAO, ...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-62832 | biostudies-arrayexpress
UnknownWhy p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding.
Not available
S-EPMC4859490 | biostudies-literature
ProteomicsProteomic analysis of E. coli K-12 LE392, P. putida KT2440 under exposure of carbamazepine
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of wild-type E. coli K-12 LE392, P. putida KT2440, and their quantitative protein response under the exposure of antiepileptic drug carbamazepine. Three concentrations of carbamazepine were applied, which were 0.05 mg...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2018-10-10 | PXD009279 | Pride
Carbamazepine Swath-ms P. putida E. coli 
ProteomicsProteomic analysis of E. coli K-12 LE392, P. putida KT2440 under exposure of six non-antibiotic pharmaceuticals
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of E. coli K-12 LE392 with conjugative RP4 plasmid, P. putida KT2440, and their protein response under the exposure of six kinds of non-antibiotic pharmaceuticals, i.e., ibuprofen (ibu), naproxen (nap), gemfibrozil (g...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2022-02-15 | PXD012642 | Pride
Non-antibiotic pharmaceuticals Swath-ms P. putida E. coli 
TranscriptomicsExpression data from +Pi and -Pi treeatment between WT and spx1spx2 double mutant
Fourteen days plants growth under hydroponic +P condition (200 µM) were treated with +P(200µM) or –P (no phosphate) for another 7 days, shoot of plants from 3 biological repeats were sampled for Affymetrix microarray analysis. We used microarrays to detail the global programme of gene expression und...
ORGANISM(S): Oryza sativa 
2014-10-03 | E-GEOD-60823 | biostudies-arrayexpress
ProteomicsA piRNA like small RNA interacts with and modulates p-ERM proteins in human somatic cells
PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC...
ORGANISM(S): Homo sapiens (Human) 
2015-09-03 | PXD002076 | Pride
Human Pull-down Lc-ms/ms 
TranscriptomicsPtr-miR397a is a negative regulator of laccase genes affecting lignin content in Populus trichocarpa
Laccases were proposed to catalyze the oxidative polymerization of monolignols. We identified 49 laccase gene models in Populus trichocarpa, of which 29 were predicted to be targets of ptr-miR397a. We overexpressed Ptr-MIR397a in transgenic P. trichocarpa. In each of all 9 transgenic lines tested, 1...
ORGANISM(S): Populus trichocarpa 
2014-01-17 | E-GEOD-54153 | biostudies-arrayexpress
TranscriptomicsExpression data from -Pi treatment between WT, phr1, phr3 and phr1phr2phr3 triple mutant
Fourteen days plants growth under hydroponic +P condition (200 μM) were treated under –P (no phosphate) condition for another 7 days, shoot of plants from 3 biological repeats were sampled for Affymetrix microarray analysis. We used microarrays to detail the global programme of gene expression unde...
ORGANISM(S): Oryza sativa Japonica Group 
2015-06-25 | E-GEOD-69010 | biostudies-arrayexpress
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