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The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of wild-type E. coli K-12 LE392, P. putida KT2440, and their quantitative protein response under the exposure of antiepileptic drug carbamazepine. Three concentrations of carbamazepine were applied, which were 0.05 mg...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2018-10-10 | PXD009279 | Pride
An antiepileptic drug carbamazepine is well tolerated by the majority of patients, but can cause severe and potentialy fatal hypersensitivity reactions in a small number of individuals. The aim of this study was to identify genetic predictors of hypersensitivity reactions to carbamazepine. We undert...
Concerns have arisen recently over the possible environmental effects of human pharmaceuticals. Although acute toxicities are low, the continuous discharge of pharmaceuticals into the aquatic environment, coupled with the fact that such compounds are selected for use on the basis of a strong pharmac...
ORGANISM(S): Salmo salar 
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, drug-induced reaction that involves both the skin and viscera. To understand the immunological components of DRESS, we prospectively assessed 40 DRESS patients. The patients were evaluated for phenotype, cytokine secretion, r...
ORGANISM(S): Homo sapiens 
Characterisation of peptides presented by the Human Leukocyte Antigen (HLA) class I molecule HLA-B*15:02 in the presence and absence of carbamazepine (CBZ), and related molecules carbamazepine-10,11-epoxide (ECBZ) and oxcarbazepine (OXC).
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD023545 | Pride
Based on the prior knowledge of involvement of the human leukocyte antigen locus in Han Chinese patients with carbamazepine-induced Stevens-Johnson syndrome, we imputed the HLA types for each case and control subject from the array of SNPs in the Human610-Quad GWAS platform (NCBI Build 36.1). We the...
Microbial communities treating synthetic wastewatrer containg carbamazepine
Proteogenomics informed by RNA-seq derived database of Dreissena polymorpha animals exposed to carbamazepine and methyl-mercury (single and co-exposures
ORGANISM(S): Dreissena polymorpha 
2023-07-25 | PXD040345 | Pride
teogenomics analysis from digestive glands from Mytilus galloprovincialis exposed to two concentrations of carbamazepine.
ORGANISM(S): Mytilus galloprovincialis (Mediterranean mussel) 
2022-04-23 | PXD024201 | Pride
we assessed characteristic molecular and proteomic signatures in rat liver treated with drugs (pyrazinamide, ranitidine, enalapril, carbamazepine, and chlorpromazine) that are known to cause DILI in humans. In the present study, we assessed the characteristic gene expression signature for DILI in a ...
ORGANISM(S): Rattus norvegicus 
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