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MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
UnknownMAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade.
Not available
S-EPMC8589317 | biostudies-literature
UnknownHNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway.
Not available
S-EPMC10010171 | biostudies-literature
UnknownAnticancer Effects of MAPK6 siRNA-Loaded PLGA Nanoparticles in the Treatment of Breast Cancer.
Not available
S-EPMC11740982 | biostudies-literature
UnknownmiR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes.
Not available
S-EPMC9622368 | biostudies-literature
UnknownUp-regulated microRNA499a by hepatitis B virus induced hepatocellular carcinogenesis via targeting MAPK6.
Not available
S-EPMC4207808 | biostudies-literature
UnknownMicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
Not available
S-EPMC5399463 | biostudies-literature
UnknownRMD and Its Suppressor MAPK6 Control Root Circumnutation and Obstacle Avoidance via BR Signaling.
Not available
S-EPMC11477179 | biostudies-literature
UnknownmiR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6.
Not available
S-EPMC7821282 | biostudies-literature
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD001085 | Pride
Mapk6 Dmog Ripk4 Erk3 Hypoxia Hydroxylases 
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