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TranscriptomicsGenetic alteration in recurrent melanoma - part 2
Studying a unique case of metastatic melanoma, we observed that cell lines derived from metachronous metastases arising over a decade retained a central core of genetic stability in spite of divergent phenotypes. In the present study we expanded our previous observations comparing these autologous c...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8778 | biostudies-arrayexpress
UnknownFuture perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".
Not available
S-EPMC3390271 | biostudies-literature
TranscriptomicsGenetic alteration in recurrent melanoma
It is generally accepted that human cancers derive from a mutated single cell. However, the genetic steps characterizing various stages of progression remain unclear. Studying a unique case of metastatic melanoma, we observed that cell lines derived from metachronous metastases arising over a decade...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8777 | biostudies-arrayexpress
TranscriptomicsGene expression profiling among human embryonic stem cells, differerentiated EBs and adult cells
Human embryonic stem (hES) cells have unique features: self-renewal ability and pluripotency. They can be continuously cultured in undifferentiated state and give rise to cells and tissues of all three germ layers. Thus hES cells provide a resource not only for cell replacement therapy but also for ...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-12228 | biostudies-arrayexpress
TranscriptomicsHuman embryonic stem cells, differerentiated EBs and adult cells
This SuperSeries is composed of the following subset Series: GSE12228: Gene expression profiling among human embryonic stem cells, differerentiated EBs and adult cells GSE12229: microRNA expression profiling among human embryonic stem cells, differerentiated EBs and adult cells Refer to individual S...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-12250 | biostudies-arrayexpress
TranscriptomicsPeripheral blood stem cell gene profiling
Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtype...
ORGANISM(S): Homo sapiens 
2010-04-01 | E-GEOD-11247 | biostudies-arrayexpress
TranscriptomicsPeripheral blood stem cell gene and microRNA profiling
Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtype...
ORGANISM(S): Human herpesvirus 4 
2010-04-01 | E-GEOD-11255 | biostudies-arrayexpress
TranscriptomicsIL-12 induces myeloid cells in situ to cross-present antigen
Myeloid-derived cells comprising the tumor stroma represent a heterogeneous population of cells critical to the structure, function and growth of established cancers. We have recently found that engineering tumor-specific CD8+ T cells to secrete IL-12 (IL-12TD) can lead to striking improvements in T...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-29164 | biostudies-arrayexpress
TranscriptomicsImiquimod treated Basal Cell Carcinoma
Imiquimod is a Toll-like receptor (TLR)-7 agonist capable of inducing complete clearance of basal cell carcinoma (BCC) and other cutaneous malignancies. We hypothesized that the characterization of the early transcriptional events induced by imiquimod may provide insights about immunological events ...
ORGANISM(S): Homo sapiens 
2006-10-04 | E-GEOD-5121 | biostudies-arrayexpress
TranscriptomicsGene expression in Bach2-deficient and wildtype CD4 single-positive thymocytes from mixed chimeric animals
The role of FoxP3+ regulatory T (Treg) cells in the maintenance of immunological tolerance is well established. Recently, genome-wide association studies (GWAS) in humans have associated polymorphisms within the BACH2 locus encoding the transcription factor BTB and CNC homology 1, basic leucine zipp...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-42598 | biostudies-arrayexpress
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