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UnknownRandomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
Not available
S-EPMC4678179 | biostudies-literature
TranscriptomicsTranscriptomic and metabolomic profiles of the Plasmodium falciparum developmental cycle
In order to further our understanding of the metabolic network of the malaria parasite, Plasmodium falciparum, we carried out a concurrent transcriptomic and metabolomic study of the parasite's intraerythrocytic developmental cycle. These microarray data were generated to compare the expression lev...
ORGANISM(S): Plasmodium falciparum 
2009-01-23 | E-GEOD-14524 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing resolves a CD4+ T cell fate bifurcation
Single-cell RNA sequencing (scRNA-seq) was used to study the various transcriptional states of individual CD4+ T cells during blood-stage Plasmodium chabaudi infection in mice. This is an experimental model of malaria in which CD4+ T cells are essential for controlling parasite numbers, and which is...
ORGANISM(S): Mus musculus 
2017-03-21 | E-MTAB-4388 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human haptocytes infected with plasmodium reveals circumsporozoite protein promotes the development of the liver stages of the Parasite
The liver stages of malaria sporozoites develop in the hepatocyte cytoplasm inside a parasitophorous vacuole (PV). The circumsporozoite (CS) protein, the major surface protein of sporozoites, traverses the PV membrane and enters the cytoplasm and nucleus of hepatocytes. CS export into the cytoplasm ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8784 | biostudies-arrayexpress
GenomicsgDNA-seq of 7G8 subclones with different var expression patterns
The parasite Plasmodium falciparum is responsible for severe malaria, which remains a major cause of death, particularly in sub-Saharan Africa. The reference strain NF54 (or its subclone 3D7) is commonly used for controlled human malaria infection (CHMI), but recently strains with a different geogra...
ORGANISM(S): Plasmodium falciparum 
2022-09-22 | E-MTAB-12158 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 7G8 cell bank parasites
The parasite Plasmodium falciparum is responsible for severe malaria, which remains a major cause of death, particularly in sub-Saharan Africa. The reference strain NF54 (or its subclone 3D7) is commonly used for controlled human malaria infection (CHMI), but recently strains with a different geogra...
ORGANISM(S): Plasmodium falciparum 7G8 
2022-09-22 | E-MTAB-12157 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of V. vinifera Cabernet sauvignon and V. aestivalis Norton innoculated with Erysiphe necator conidiospores
we analyzed pathogen-induced changes in the transcriptome of Vitis vinifera ‘Cabernet sauvignon’ and Vitis aestivalis ‘Norton’ by conducting a large-scale study to measure transcript abundance at 0, 4, 8, 12, 24, and 48 hours post-treatment in conidiospore- and mock-inoculated leaves using A...
ORGANISM(S): Vitis aestivalis 
2008-06-14 | E-GEOD-6404 | biostudies-arrayexpress
TranscriptomicsEarly Genomic Amplifications in Blood-Stages of ARMD Plasmodium falciparum Acquiring De Novo Drug Resistance [Expression]
While many molecular changes associated with commonly used antimalarials are known, there remain important questions on how parasites arrive at the correct causal molecular solutions in a haploid genome. We selected for resistance to DSM1, a novel dihydroorotate dehydrogenase (DHODH) inhibitor wit...
ORGANISM(S): Plasmodium falciparum Dd2 
2013-05-01 | E-GEOD-35949 | biostudies-arrayexpress
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
TranscriptomicsInhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease
Huntington Disease (HD) is a dominantly inherited, relentlessly progressive neurodegenerative disease. Caused by a polyglutamine expansion in the mutant huntingtin protein (mhtt), HD pathogenesis impairs function in the cerebral cortex and in medium spiny neurons of the striatum and involves transc...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21237 | biostudies-arrayexpress
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