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GenomicsCapture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Multiple regulatory elements distant to their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functi...
EGAS00001001085 | EGA
Genomicsena-DATASET-ICR-PTGT-05-02-2015-11:21:41:591-6 - samples
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
EGAD00001001243 | EGA
TranscriptomicsTranscriptome of soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8550 | biostudies-arrayexpress
TranscriptomicsMOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The recent identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of addi...
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-65068 | biostudies-arrayexpress
ProteomicsHepatitis C virus alters the morphology and function of peroxisomes.
Despite the introduction of effective treatments for hepatitis C in clinics, issues remain regarding the liver diseases induced by chronic hepatitis C virus (HCV) infection. HCV is known to disturb the metabolism of infected cells, especially lipid metabolism and redox balance, but the mechanisms le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044994 | Pride
Crispr-cas9 Peroxisome Apex2 Jfh1 Dbn3a Proximity biotinylation Ros Hepatitis c virus Hcv genotype 
TranscriptomicsTranscriptome of reloaded soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8551 | biostudies-arrayexpress
TranscriptomicsWhole genome expression data comparison between WT and Cebpg-/- MEFs.
C/EBPβ is an important regulator of oncogene-induced senescence (OIS). Here we show that C/EBPγ, a heterodimeric partner of C/EBPβ whose biological functions are not well understood, inhibits cellular senescence. Cebpg-/- MEFs proliferated poorly, entered senescence prematurely, and expressed a p...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-47777 | biostudies-arrayexpress
ProteomicsExpression of a surfactant protein C mutation impairs postnatal expansion of alveolar type 2 epithelial cells leading to permanent cell loss and decreased repair capacity in adult lungs
Mutations in the gene encoding surfactant protein C (SFTPC) are associated with interstitial lung disease in children and adults. To assess the natural history of disease, we knocked-in a familial, disease-associated SFTPC mutation, L188Q (L184Q in mice), into the mouse Sftpc locus. Expression of th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-08-19 | MSV000085976 | MassIVE
ProteomicsSpatial control of the APC/C ensures the rapid degradation of Cyclin B1
The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is under the control of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). The Checkpoint prev...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052677 | Pride
Apc/c Cyclin b1 
UnknownAssessing the Practical Differences in LDL-C Estimates Calculated by Friedewald, Martin/Hopkins, or NIH Equation 2: An Observation Cross-Sectional Study.
Not available
S-EPMC10548185 | biostudies-literature
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