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TranscriptomicsMapping of MLE and MSL2 using iCLIP
Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and long non-coding RNAs (lncRNAs) for transcriptional up-regulation of the entire X-chromosome. Here, UV cross-linking followed by deep sequencing (iCLIP) show that two enzymes in the Male-Specific Lethal complex, MLE ...
ORGANISM(S): Drosophila melanogaster 
2013-07-18 | E-MTAB-1669 | biostudies-arrayexpress
UnknownClinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastases.
Not available
S-EPMC4451171 | biostudies-literature
ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD014420 | Pride
Proteome solubility Proteomics Stress response Proteostasis 
ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD015573 | Pride
Metabolism Huntington’s disease Protein homeostasis Protein aggregation Er-mediated folding inhibition Stress granule formation Aggregomics Nuclear pore Hsp70 Protein misfolding Molecular chaperones Oxidative stress Hsp90 Proteasome 
GenomicsBIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues
C-MYC (henceforth MYC) is one of the most frequently overexpressed oncogenes in human cancer and even modestly deregulated MYC expression can initiate ectopic proliferation in many post-mitotic, terminally differentiated cell types in vivo. Metazoan organisms have consequently evolved a number of me...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-59001 | biostudies-arrayexpress
TranscriptomicsDifferential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes
Analysis of microRNA expression in vastus lateralis muscle biopsies from 11 genetically identical twin pairs discordant for type 2 diabetes. This eliminates the influence of genotype and leads to the identification of microRNAs that are exclusively influenced by environmental (non-genetic) factors. ...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-38835 | biostudies-arrayexpress
TranscriptomicsBezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), is generally used to treat hyperlipidemia. Clinical trials on patients suffering from type 2 diabetes indicated that BEZ also has beneficial effects on glucose metabolism, but the underlying mechanisms remain ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-79008 | biostudies-arrayexpress
GenomicsGenome-wide profiling of the meiotic recombinase DMC1, the chromosome axis protein ASY1 and chromatin states in hexaploid wheat (ChIP-seq)
We performed ChIP-seq for the meiotic strand exchange protein DMC1, which marks an early stage in the meiotic recombination pathway, and the chromosome axis protein ASY1, which promotes interhomolog synapsis and recombination in plants, using tissue collected from immature pre-emergence spikes from ...
ORGANISM(S): Triticum aestivum 
2021-07-07 | E-MTAB-9632 | biostudies-arrayexpress
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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