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TranscriptomicsSystematic meta-analysis and replication of genome-wide expression studies of Parkinson's disease: 2
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease. Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD). The substantia nigra samples from 8 PD subjects were obtained from the ...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-20163 | biostudies-arrayexpress
TranscriptomicsMethylome profiling of human glioblastoma using Illumina 450K microarrays for the GlioTeX panel
Genome-wide methylation profiles were generated as part of a multi-omics characterization (SNP array, WES, RNA-seq, cDNA microarray) of a panel of gliomasphere cell lines and matched parental tumors. See https://www.ncbi.nlm.nih.gov/pubmed/27571888 about the GlioTeX panel. Methylation profiling d...
ORGANISM(S): Homo sapiens 
2017-06-24 | E-MTAB-5797 | biostudies-arrayexpress
UnknownAssociations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
Not available
S-EPMC10352930 | biostudies-literature
UnknownAnalysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.
Not available
S-EPMC3271045 | biostudies-literature
ProteomicsPDGF-hSyn Synaptosomes (vGlut FASS) nanoLC-MS/MS
This project studies the differential abundance of proteins at excitatory synapses of PDGF-hSyn mice (Masliah et al., 2000, Science), which are a model for Parkinson’s disease/dementia with Lewy bodies. The mice overexpress human alpha synuclein under the human PDGF promoter. Synapses were purified ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-02 | PXD006812 | Pride
Vglut Lewy body Synaptosome Excitatory synapse Parkinson’s diseas 
Unknownalpha-synuclein promotes mitochondrial deficit and oxidative stress.
Not available
S-EPMC1850140 | biostudies-literature
ProteomicsAlzheimer's disease proteomics
This project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pa...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-12-19 | MSV000080431 | MassIVE
TranscriptomicsTranscription profiling of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age.
Microarray comparison of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age. RNA was extracted from substantia nigral cells that were isolated by laser capture microdissection.
ORGANISM(S): Mus musculus 
2007-12-20 | E-MEXP-1383 | biostudies-arrayexpress
UnknownIn vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Not available
S-EPMC3585072 | biostudies-literature
UnknownMEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.
Not available
S-EPMC3162026 | biostudies-literature
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