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ProteomicsRecurrent innovation of protein-protein interactions in the Drosophila piRNA pathway
Despite being essential for fertility, genome defence pathway genes often evolve rapidly. However, little is known about the molecular basis of this adaptation. Here, we characterize the evolution of a protein interaction network within the PIWI-interacting small RNA (piRNA) genome defence pathway i...
ORGANISM(S): Drosophila persimilis Drosophila simulans Drosophila virilis Drosophila melanogaster (Fruit fly) Drosophila erecta 
2024-10-05 | PXD053049 | Pride
Pirna pathway Inter and intra lethalities Drosophila Species-specific protein interactions Evolution 
ProteomicsMutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis
ATGL is the key enzyme in intracellular lipolysis playing a critical role in metabolic and cardiovascular diseases. ATGL is tightly regulated through a known set of protein-protein interaction partners with activating or inhibiting functions in control of lipolysis. However, the binding mode and pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD049436 | Pride
Deep mutagenesis Cidec Plin5 Plin1 Atgl G0s2 Cgi-58 
ProteomicsSpermidine is essential for fasting-mediated autophagy and longevity
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health 1. The natural polyamine spermidine has been linked to autophagy regulation, geroprotection and reduced incidence of cardiovascular and neurodegenerative diseases across speci...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-04-30 | PXD035909 | Pride
Autophagy Nanolc-ms/ms Spermidin Fasting Yeast Human Lifespan Eif5a hypusination Mouse C.elegans 
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