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TranscriptomicsDNA copy number profiling of canine osteosarcoma
Identification of DNA copy number imbalances in 22 spontaneous canine osteosarcoma cases using array comparative genomic hybridization (aCGH) analysis
ORGANISM(S): Canis familiaris 
2013-11-01 | E-MTAB-1986 | biostudies-arrayexpress
TranscriptomicsT (Brachyury) gene duplication confers major susceptibility to familial chordoma
Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex (≥ with ≥ 3 cases) families of chordoma, a cancer of presumed notochordal origin. comparison of test samples from chordoma families to a reference DNA sample
ORGANISM(S): Homo sapiens 
2009-10-04 | E-GEOD-17668 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures
Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial survival or death at supra-physiological temperatures. This study analyzed diverse facets...
ORGANISM(S): Staphylococcus aureus 
2010-06-19 | E-GEOD-12920 | biostudies-arrayexpress
GenomicsGenome wide promoter methylation analysis of mouse macrophages and endothelial cells isolated from ischemic hindlimbs using RRBS sequencing
Purpose: The goal of this study was to compare the genome-wide promoter methylation alterations in macrophages and endothelial cells during hindlimb ischemia among normal, hyperlipidemic and type-2 diabetic mice. Methods: Unilateral hindlimb ischemia was induced by ligating femoral artery proximal t...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-65759 | biostudies-arrayexpress
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but dev...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47735 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blood cells from hypertriglyceridemic men treated with docosahexaenoic acid shows suppression of LDLR and OLR1 gene expression.
Previously published results from our double-blind, placebo-controlled parallel study with docosahexaenoic acid (DHA) supplementation (3 g/d, 90 d) to hypertriglyceridemic men (39-66yr) showed that DHA reduced several risk factors for cardiovascular disease (CVD), including the plasma concentration ...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20114 | biostudies-arrayexpress
TranscriptomicsGene expression data from human metastatic melanoma tumors that may predict response to RAF265
To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control gr...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-30812 | biostudies-arrayexpress
TranscriptomicsIntegrating phenotypic and expression profiles to map arsenic response networks
The parent S. cerevisiae strain, BY4741, and specific gene deletions of the parent S.cerevisiae strain BY4741 were treated with 100uM NaAsO2 (AsIII) for 2h and compared to the untreated counterpart (yap1Î? vs. yap1Î? 2h 100uM AsIII, cad1Î? vs. cad1Î? 2h 100uMAsIII, rpn4Î? vs. rpn4Î? 2h 100uM AsIII, ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-1798 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mosquitos fed blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain
Female mosquitoes fed with blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain. We used CTRPko-infected midguts as reference, as they experience pre-invasion conditions similar to thos...
ORGANISM(S): Anopheles gambiae 
2005-07-12 | E-MEXP-378 | biostudies-arrayexpress
TranscriptomicsWidespread RNA Binding by Chromatin Associated Proteins
Recent evidence suggests that RNA interaction can regulate the activity and localization of DNA binding proteins, particularly chromatin-associated proteins. However, it is unknown if these observations are specialized instances for a few key RNAs and chromatin factors in specific contexts, or a gen...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-67963 | biostudies-arrayexpress
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