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TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP]
Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish i...
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33569 | biostudies-arrayexpress
ProteomicsL-Glyceraldehyde inhibits neuroblastoma cell 1 growth via a multi-modal mechanism on metabolism 2 and signaling
Glyceraldehyde (GA) is a 3-carbon monosaccharide that can be present in cells as a by-product of fructose metabolism. Bruno Mendel and Otto Warburg showed that the application of GA to cancer cells inhibits glycolysis and their growth. This phenomenon was extensively studied up until the 1970’s. How...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048695 | Pride
Metabolism Neuroblastoma Cancer Redox Glycolysis 
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites
This SuperSeries is composed of the following subset Series: GSE33569: In vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP] GSE33573: In vivo and transcriptome-wide identification of RNA-binding protein target sites [RNA-Seq] Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33543 | biostudies-arrayexpress
ProteomicsVigilin/HDLBP promotes translation of endoplasmic reticulum-targeted mRNAs
Nascent peptide chain targeting to the endoplasmic reticulum (ER) membrane is required for correct localization and efficient translation of membrane-bound and secreted proteins. However, little is known about the contribution of RNA-binding proteins (RBPs) to the recognition, localization and trans...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD018313 | Pride
Hdlbp  vigilin  rna-binding protein  kh-domain  endoplasmic reticulum  translation  homo sapiens  qexactive hf 
Proteomics5 cell lines - Deep proteome analysis of 5 cell lines (WI38, Hep2G, MCF-10A, MDA-MB-231, MCF7), using peptide isolectic focusing fractionation.
Deep proteome analysis of 5 cell lines (WI38, Hep2G, MCF-10A, MDA-MB-231, MCF7), using peptide isolectic focusing fractionation.
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD002400 | Pride
Ltq velos orbitrap 
ProteomicsC/EBPβ-LIP regulates the let-7/Lin28b circuit to induce cancer-type metabolic reprogramming
The RNA binding protein Lin28b is highly expressed during embryogenesis but its expression declines in adult tissues, and aberrant expression of Lin28b is associated with tumour development and maintenance. Lin28b regulates the translation of several glycolytic and mitochondrial enzymes in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010095 | Pride
Q exactive hf Shotgun proteomics 
ProteomicsExtensive folding variability between homologous chromosomes in mammalian cells
Genetic variation and 3D chromatin structure have major roles in gene regulation. Structural differences between genotypically different chromosomes and their effects on gene expression remain ill understood, due to challenges in mapping 3D genome structure with allele-specific resolution. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD048969 | Pride
Lc-msms Genome architecture mapping (gam) Chromatin Polycomb 
ProteomicsHepatomasys
Metabolic alterations can serve as targets for diagnosis and therapy of cancer. Due to the highly complex regulation of cellular metabolism, definite identification of metabolic pathway alterations remains challenging and requires sophisticated experimentation. Here, we applied a comprehensive kinet...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011162 | Pride
Shotgun proteomics Mass spectrometry Liver cancer Hepatocellular carcinoma 
ProteomicsSystems biology decodes herpes simplex virus 1
Since the genome of herpes simplex virus 1 (HSV-1) was first sequenced more than 30 years ago, the 84 genes it was thought to encode have been intensively studied. Here, we unravel the full complement of viral transcription and translation during lytic infection with base-pair resolution by computat...
ORGANISM(S): Homo sapiens (Human) Herpes simplex virus unknown type 
2020-05-22 | PXD013407 | Pride
Shotgun proteomics Genome annotation Systems biology 
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites [RNA-Seq]
Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish i...
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33573 | biostudies-arrayexpress
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