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TranscriptomicsTranscription profiling by array of human olfactory neurosphere derived (ONS) cells to investigate a patient-specific olfactory stem cell disease model for ataxia-telangiectasia.
Nasal biopsies were collected from control and A-T patients prior to establishing olfactory neurosphere derived (ONS) cells. These cells were phenotyped using stem cell markers, a series of A-T cellular characteristics determined and cells differentiated into neuronal cells.
ORGANISM(S): Homo sapiens 
2013-01-10 | E-MTAB-1217 | biostudies-arrayexpress
TranscriptomicsA patient-derived neural stem cell model for hereditary spastic paraplegia
Hereditary Spastic Paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPG4 are a major cause of autosomal-dominant HSP. Spastin, the protein encoded by SPG4, is a microtubule-severing protein and is enriched in the distal axon of cor...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-TABM-1180 | biostudies-arrayexpress
TranscriptomicsRotenone susceptibility phenotype in olfactory derived patient cells as a model of idiopathic Parkinson’s disease
Physiologically relevant cellular models are critical for understanding complex pathological processes. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by motor and non-motor symptoms. Several cellular models for PD have been developed to reproduce the a...
ORGANISM(S): Homo sapiens 
2016-10-04 | E-MTAB-4164 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monozygotic twins discordant for bipolar disorder
To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic tw...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7036 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of fibroblasts from eight individuals to evaluate variability in the establishment of induced pluripotent stem cell lines and to develop future cellular models of disease.
Fibroblasts from eight individuals were chosen to evaluate variability in the establishment of iPSC lines and to develop future cellular models of disease. From the eight patients four were healthy controls (Cont) and four were schizophrenic (Sz). All the patients were males with ages ranging from 2...
ORGANISM(S): Homo sapiens 
2012-09-29 | E-MTAB-1040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of differences between multipotent stromal cells isolated from human bone marrow, umbilical cord blood and placenta
Unrestricted somatic stem cells (USSCs) from human cord blood show distinct differences to multipotent stromal cells isolated from human bone marrow and placenta both at the gene array and functional level. Fibroblast samples and raw data also included in E-TABM-724.
ORGANISM(S): Homo sapiens 
2014-11-26 | E-TABM-880 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human olfactory neurosphere-derived cell lines from healthy and idiopathic Parkinsons disease individuals.
The human olfactory epithelium represents a readily accessible source of adult neural cell types which can be propagated in vitro. We have used this feature to establish olfactory neurosphere-derived (hONS) cells lines from patients with idiopathic Parkinson's disease (PD) and healthy controls. We i...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-TABM-879 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neurosphere-derived cell lines from patients with brain disorders
Understanding the molecular bases of neurological and psychiatric conditions is hampered by a lack of suitable patient-derived cellular models. The olfactory mucosa is a continually regenerating neural tissue that contains multipotent neural stem cells which are accessible and expandable in vitro as...
ORGANISM(S): Homo sapiens 
2010-06-04 | E-TABM-724 | biostudies-arrayexpress
TranscriptomicsDNA methylation in schizophrenia in different patient-derived cell types
DNA methylation of gene promoter regions represses transcription and is a mechanism via which environmental risk factors could affect cells during development in individuals at risk for schizophrenia. We investigated DNA methylation in patient-derived cells that might shed light on early development...
ORGANISM(S): Homo sapiens 
2017-11-01 | E-MTAB-5016 | biostudies-arrayexpress
TranscriptomicsTolerogenic dendritic cells protect against acute kidney injury
We use tolDCs from syngeneic (C57BL6) and allogeneic (BALB/c) mice to show potent renoprotective abilities in a ischemia reperfusion AKI model. Dendritic cells were derived from mice bone marrow and cultured for 7 days with GM-CSF and IL-4. Tolerogenic DCs were cultured in the same DC media but with...
ORGANISM(S): Mus musculus 
2024-11-25 | E-MTAB-14618 | biostudies-arrayexpress
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