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TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
UnknownSingle-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.
Not available
S-EPMC6719422 | biostudies-literature
UnknownHuman Kallikrein 2: A Novel Lineage-Specific Surface Target in Prostate Cancer.
Not available
S-EPMC12580770 | biostudies-literature
UnknownTargeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.
Not available
S-EPMC8971766 | biostudies-literature
UnknownHuman aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
Not available
S-EPMC2847746 | biostudies-literature
TranscriptomicsMicroarray of zebrafish (Danio rerio) sfpq-/-;Tg(mnx1:GFP) against sfpq+/+;Tg(mnx1:GFP) and sfpq+/-;Tg(mnx1:GFP) siblings at 24 hpf
Phenotypic characterisation of our zebrafish sfpq homozygous mutants revealed a restricted set of specific defects, unexpected for a protein expressed ubiquitously and involved in such general mechanisms. The CNS was prominently affected, showing brain boundary and axonal defects associated with abs...
ORGANISM(S): Danio rerio 
2017-09-01 | E-MTAB-5559 | biostudies-arrayexpress
UnknownGene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.
Not available
S-EPMC5302866 | biostudies-literature
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
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