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ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080198 | MassIVE
ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo sapiens (Human) 
2016-08-09 | PXD004089 | Pride
Ap-ms Bioid Mcm complex 
ProteomicsMCM proteins are up-regulated in placentas of women with reduced insulin sensitivity
In the first trimester of pregnancy the human placenta grows rapidly, making it sensitive to changes in the intrauterine environment. To test whether exposure to an environment in utero often associated with obesity modifies placental proteome and function, we performed untargeted proteomics (LC-MS/...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056380 | Pride
Obesity Placenta Mcm-complex Early pregnancy Insulin Oxygen Placenta-growth Dna-damage repair Insulin sensitivity Trophoblast 
ProteomicsDestabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks induced by Etoposide.
DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is only replicated once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both initiation of DNA replication and elongat...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009539 | Pride
Dna repair Mcm protein Etoposide Dna damage Homologous recombination 
UnknownEukaryotic MCM proteins: beyond replication initiation.
Not available
S-EPMC362110 | biostudies-literature
UnknownThree Different Interaction Patterns between MCM-41 and Proteins.
Not available
S-EPMC9781137 | biostudies-literature
OtherA new MCM modification cycle regulates DNA replication initiation
The hexameric DNA helicase MCM (Mcm2-7) is a central regulatory target in eukaryotic replication. Chromatin-bound MCM is kept inactive during G1 phase and subsequently activated in S phase to initiate replication. During this transition, the only known chemical change on the Mcm2-7 proteins is the g...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-01 | GSE70407 | GEO
UnknownInteractions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties.
Not available
S-EPMC1201339 | biostudies-literature
UnknownAncient diversification of eukaryotic MCM DNA replication proteins.
Not available
S-EPMC2667178 | biostudies-literature
ProteomicsInhibitory effect of miR-183 on MCM family members
MYCN and HDAC2 jointly repress the transcription of tumor suppressive micro RNA miR-183 in neuroblastoma. Enforced miR-183 expression induces neuroblastoma cell death and inhibits anchorage-independent colony formation and subcutaneous xenograft growth in mice. We here aimed to unravel the miR-183 s...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003596 | Pride
Label-free proteomics Cell cycle progression Eukaryotic genome replication Oncogene Genomic integrity 
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