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ProteomicsMitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Sustained and balanced Ca2+ increase upon T-cell receptor activation is crucial for regulation of essential T-cell functions including clonal expansion, differentiation and cytokine secretion. Thereby, mitochondria play an important role and take up Ca2+ to support elevated bioenergetic demands. The...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-23 | PXD048650 | Pride
Metabolism Eae Calcium Mitochondria Autoimmunity T-cell Mcu 
ProteomicsMitochondrial calcium uniporter complex controls T‑cell‑mediated immune responses
Sustained and balanced calcium (Ca2+) increase upon T-cell receptor activation is a fundamental process that regulates essential T-cell functions including proliferation, clonal expansion and cytokine secretion. In this context, mitochondria play an important role and take up Ca2+ to support the ele...
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD048682 | Pride
Mcu/autoimmunity/calcium/eae/metabolism/mitochondria/t-cell 
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