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TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
TranscriptomicsComparative genomic hybridization of frozen salivary or pulmonary adenoid cystic carcinoma samples and normal tissue to identify copy number alterations
Adenoid cystic carcinoma (AAC) is a rare but distinctive tumor. Array comparative genomic hybridization (CGH) has been applied for detecting chromosomal copy number alterations in seventeen frozen salivary or pulmonary ACCs samples. There were recurrent gains at 1p36, 6p21, 16q24, 17q21, and 22q11-1...
ORGANISM(S): Homo sapiens 
2008-04-18 | E-TABM-267 | biostudies-arrayexpress
TranscriptomicsNanostring microRNA microarry analysis of p53 and Mdm2 knockout mouse hearts compared to vehicle-injected negative controls
Adult cardiomyocytes (CM) are terminally differentiated cells with minimal regenerative capacity, making cardiac tissue particularly vulnerable to injury. Thus, defining the roadblocks responsible for adult CM cell cycle arrest lies at the core of developing therapies to regenerate myocyte loss foll...
ORGANISM(S): Mus musculus 
2017-03-22 | E-MTAB-5531 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of intestine from wild type and Mdm2 knock-out mice
Analyzed gene expression in 3-day old mice lacking Mdm2 in the intestine
ORGANISM(S): Mus musculus 
2008-03-23 | E-MEXP-1431 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptome analyses of transgenic mice, that express Cre recombinase flanked by mutated estrogen receptors (MerCreMer; mcm), and carry loxP-flanked sequences of p53 and Mdm2 was performed in the presence and absence of Tamoxifen
Genome-wide transcriptome analyses of transgenic mice, that express Cre recombinase flanked by mutated estrogen receptors (MerCreMer; mcm), and carry loxP-flanked sequences of p53 and Mdm2 was performed in the presence and absence of Tamoxifen.
The molecular mechanisms underlying heart failure re...
ORGANISM(S): Mus musculus 
2017-02-23 | E-MTAB-5441 | biostudies-arrayexpress
UnknownInduction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.
Not available
S-EPMC11295014 | biostudies-literature
UnknownRBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma.
Not available
S-EPMC6122209 | biostudies-literature
UnknownKaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.
Not available
S-EPMC2698538 | biostudies-literature
UnknownUNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.
Not available
S-EPMC6125449 | biostudies-literature
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