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TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bladder smooth muscle cells subjected to cyclic stretch-relaxation
The aim of the experiment was to determine the effect of cyclic stretch-relaxation ("stretch") on gene expression patterns in normal diploid human bladder smooth muscle cells. Cells plated on silicone elastomer bottomed 6-well culture dishes were grown to ~80% confluence, serum-depleted for 48h and ...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1595 | biostudies-arrayexpress
ProteomicsMulti-omics analyses reveal the mechanical-stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the ocular pulse created by the cardiac cycle. This induces alterations in membrane lipids and associated cell-cell adhesion and cell-extracellular matrix (ECM) interactions triggering intracellular signaling responses...
ORGANISM(S): Homo sapiens (Human) 
2022-08-30 | PXD031347 | Pride
Cyclic mechanical stretch Human trabecular meshwork Global proteomic analysis (lc-ms/ms) Mrna sequencing. Lipidomic analysis 
TranscriptomicsTranscription profiling of human bronchial epithelial cells exposed to cyclic stretch with and without LPS or TNFa
Acute respiratory distress syndrome (ARDS) is a catastrophic form of acute lung injury (ALI). The necessity for mechanical ventilation (MV) renders patients at risk for ventilator induced lung injury (VILI). Exposure to repetitive cyclic stretch (CS) and/or over-inflation exacerbates injury. Reducin...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-16650 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lamina cribrosa cells in vitro treated with mechanical strain
The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the l...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3166 | biostudies-arrayexpress
TranscriptomicsCyclic mechanical stretch-induced gene expression
With gene expression profiling it was aimed to identify the differentially expressed genes associated with the regulation of the cytoskeleton to investigate the stretch-induced cell alignment mechanism. A whole genome microarray based analysis of the stretch-induced gene expression changes was done....
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-58389 | biostudies-arrayexpress
ProteomicsPhosphoproteomic Network Analysis Reveals Molecular Mechanisms of Myometrial Stretch Response
Mechanical stress is a potent regulator of cell growth, contractility and gene regulation. Abnormal uterine distension during pregnancy increases the risk of preterm birth and likely activates crosstalk between multiple signaling networks with protein phosphorylation playing a critical role. Telomer...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD002538 | Pride
Human Cell culture Myometrium Uterus Distension Phosphoproteomic Stretch 
GenomicsComprehensive analysis of differentially expressed genes responsed to mechanical stretch in human corneal keratocytes.
Comprehensive analysis of differentially expressed genes responsed to mechanical stretch in human corneal keratocytes.
PRJNA510829 | ENA
GenomicsMechanical stretch induced transcriptomic profiles in cardiac myocytes II
Mechanical stretch induced transcriptomic profiles in cardiac myocytes II
PRJNA420515 | ENA
GenomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
The ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
PRJEB70944 | ENA
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