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MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_MALDI imaging]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12601 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
ProteomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration
Mechanical forces altered after unilateral pneumonectomy (PNX) control post-PNX lung growth. Here we demonstrate that post-PNX vascular formation is stimulated at the peripheral region of the mouse lung requiring focal adhesion protein, paxillin, while inhibition of mechanical tension attenuates the...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-19 | PXD038600 | Pride
Angiogenesis Angiopoietins Lung regeneration Paxillin Mechanical tension 
ProteomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Phosphoproteomics]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
ORGANISM(S): Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) 
2025-06-18 | PXD064017 | Pride
Mechanical stress Xylem development Tension wood Cell fate determination Lc-ms/ms Phosphoproteome Gravity sensing 
GenomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration [scRNA-seq]
Mechanical tension-induced spatial control of angiogenesis during lung regeneration [scRNA-seq]
PRJNA1144918 | ENA
GenomicsMaintenance of primary hepatocyte functions in vitro by inhibiting mechanical tension-induced YAP activation
Maintenance of primary hepatocyte functions in vitro by inhibiting mechanical tension-induced YAP activation
PRJNA574958 | ENA
ProteomicsImportin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement
Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenes...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-06 | PXD061760 | Pride
Runx2 Mechanotransduction Ipo7 Tooth movement Nuclear translocation Alveolar bone remodeling 
GenomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration [RNA-seq dataset I]
Mechanical tension-induced spatial control of angiogenesis during lung regeneration [RNA-seq dataset I]
PRJNA907364 | ENA
GenomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration [RNA-seq dataset II]
Mechanical tension-induced spatial control of angiogenesis during lung regeneration [RNA-seq dataset II]
PRJNA961093 | ENA
TranscriptomicsMaintenance of primary hepatocyte functions in vitro by inhibiting mechanical tension-induced YAP activation
It has been a long-standing challenge to maintain the functions of hepatocytes in vitro. In the present study, we found that mechanical tension-induced yes-associated protein (Yap) activation triggered hepatocyte dedifferentiation. Alleviation of mechanical tension by confinement of cell spreading w...
ORGANISM(S): Mus musculus 
2019-10-30 | GSE138158 | GEO
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