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Social isolation poses a severe mental and physiological burden on humans. Most animal models that investigate this effect are based on prolonged isolation, which does not mimic the milder conditions experienced by people in the real world. Here we show that in the medial amygdala, a brain structure...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-03 | PXD026871 | Pride
Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala
The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice
bulk RNAseq from the medial amygdala of male and female mice
Single-cell RNA sequencing of male and female mouse medial amygdala using Drop-Seq
ORGANISM(S): Mus musculus 
2019-02-14 | GSE124061 | GEO
Moderate caloric restriction (CR) and weight loss are beneficial for the promotion of health; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily feeding of ...
ORGANISM(S): Mus musculus 
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists have demonstrated therapeutic properties for several brain disorders, including alcohol depen...
ORGANISM(S): Mus musculus 
In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previo...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD026978 | Pride
Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward
Little is known about how Kiss1 cells in the medial amygdala (MeA) are regulated and what other gene transcripts are produced by MeA Kiss1 neurons. Estradiol upregulates Kiss1 expression in the medial amygdala (MeA), but it remains unknown if estradiol regulates other gene transcripts in MeA Kiss1 c...
ORGANISM(S): Mus musculus 
2023-02-13 | GSE224788 | GEO
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