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ProteomicsComparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
A substantial part of cutaneous malignant melanomas develops from benign nevi. However, the precise molecular events driving the transformation from benign to malignant melanoma are not well understood. We used laser microdissection and mass spectrometry to analyze the proteomes of melanoma subtypes...
ORGANISM(S): Homo sapiens (Human) 
2024-01-28 | PXD044107 | Pride
Human Nevus-associated melanoma Proteomics Microdissection Skin cancer Skin Melanoma subtypes Ffpe Nevi Malignant melanoma 
ProteomicsProteogenomics linked to histopathology identifies subtypes and progression biomarkers in malignant melanoma
In this study, proteogenomic analysis coupled with clinical histopathology revealed proteomic subtypes and identified candidate markers, which uncovered tumor biology related to patient survival. A total of 12,695 proteins and 45,356 phosphosites were quantified. This newly generated proteomic data ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD035206 | Pride
Cancer Proteomics Mass spectrometry Melanoma Proteogenomics Metastasis 
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, fractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080282 | MassIVE
GenomicsComparative genomics of melanoma subtypes
Comparative genomics of melanoma subtypes
PRJNA834658 | ENA
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, unfractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080280 | MassIVE
UnknownComparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes.
Not available
S-EPMC9716259 | biostudies-literature
TranscriptomicsCharacterization of the melanoma miRNAome by deep sequencing
MicroRNAs are 18-23 nucleotide non-coding RNAs that regulate gene expression in a sequence specific manner. Little is known about the repertoire and function of miRNAs in melanoma or the melanocytic lineage. We therefore undertook a comprehensive analysis of the miRNAome in a diverse range of pigmen...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-18381 | biostudies-arrayexpress
TranscriptomicsExpression data from human metastatic melanoma cell lines
The genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, that included expression of mRNAs regulated by either transforming g...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-56717 | biostudies-arrayexpress
ProteomicsHigh-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Remodeling in Acral Melanoma
Formalin-fixed, paraffin-embedded (FFPE) archives underpin dermatopathology and translational oncology, enabling clinically annotated melanoma cohorts, but cohort-scale proteomics remains limited by labor and variability in upstream processing. We established a plate-scale, acoustic FFPE proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD074156 | Pride
Ai-digital pathology  atp synthase inhibitor if1  adaptive focused acoustics  acral melanoma Oxidative phosphorylation  plate-scale ffpe proteomics 
TranscriptomicsImatinib targeting of KIT-mutant oncoprotein in melanoma
Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, f...
ORGANISM(S): Homo sapiens 
2008-12-23 | E-GEOD-8164 | biostudies-arrayexpress
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