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TranscriptomicsTranscription profiling of C. elegans aging in 5 individuals of each age (4,9,14,or 19 days) of each of two genotypes (N2 or daf-2)N2 daf-2
Gene expression profiles were generated for 4-5 individuals of each age (4,9,14,or 19 days) of each of two genotypes (N2 or daf-2)
ORGANISM(S): Caenorhabditis elegans 
2009-07-01 | E-MEXP-138 | biostudies-arrayexpress
TranscriptomicsAge-related behaviors have distinct transcriptional profiles in C. elegans
There has been a great deal of interest in identifying potential biomarkers of aging (Butler et al. 2004). Biomarkers of aging would be useful to predict potential vulnerabilities in an individual that may arise well before they are chronologically expected, due to idiosyncratic aging rates that occ...
ORGANISM(S): Caenorhabditis elegans 
2008-09-16 | E-GEOD-12290 | biostudies-arrayexpress
TranscriptomicsLimb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine a...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14901 | biostudies-arrayexpress
TranscriptomicsEccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways
Full title: Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. Unaccustomed eccentric exercise damages muscle tissue stimulating mechanisms of recovery and remodeling that may be affected by cellular protection by the sex...
ORGANISM(S): Homo sapiens 
2009-12-16 | E-GEOD-19062 | biostudies-arrayexpress
TranscriptomicscDNA microarray analysis of human skeletal muscle after endurance exercise
We examined global mRNA expression using cDNA microarrays in skeletal muscle of humans before, and 3h and 48h after a single bout of exhaustive endurance exercise (cycling). Keywords: Time course Healthy, non-trained university-aged subjects performed a single bout of exhaustive cycling. Skeletal ...
ORGANISM(S): Homo sapiens 
2006-02-17 | E-GEOD-4247 | biostudies-arrayexpress
TranscriptomicsInsulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.
The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and...
ORGANISM(S): Caenorhabditis elegans 
2010-06-17 | E-GEOD-22383 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NIH3T3 cells transformed with oncovav2 deprived of Serum
Effect of the overexpression of the oncogenic form of the Vav2 protein in the NIH3T3 cell line under serum deprivation conditions. oncovav2-transformed NIH3T3 cells grown in serum-deprived medium (Vav2SD) are compared to the parental NIH3T3 controls under the same growth conditions (ContSD). Vav2SD ...
ORGANISM(S): Mus musculus 
2005-06-22 | E-MEXP-137 | biostudies-arrayexpress
TranscriptomicsLate life rapamycin treatment reverses age-related heart dysfunction
We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly different...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-48043 | biostudies-arrayexpress
TranscriptomicsIntra-myocellular fatty acid synthesis and breakdown plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster
Dietary restriction (DR) is a robust environmental intervention that slows aging in various species. Changes in fat content have been associated with DR, but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shi...
ORGANISM(S): Drosophila melanogaster 
2012-06-14 | E-GEOD-37537 | biostudies-arrayexpress
TranscriptomicsMassage therapy attenuates NFκB nuclear accumulation and inflammatory cytokine production following damage in human skeletal muscle
Massage therapy is commonly used for the physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. While there is some evidence that massage may relieve pain in injured muscle, the cellular effects remain unknown. To assess the effects of massage, we administer...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-33603 | biostudies-arrayexpress
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