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ProteomicsBone marrow mesenchymal stem cells’ secretome exerts neuroprotective effects in a Parkinson’s disease rat model
Parkinson’s disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014887 | Pride
Neuroprotection Dopamine neurons Secretome Mesenchymal stem cells Parkinson's diasese 
ProteomicsDeciphering Early Pathogenic Changes in Alzheimer's disease
The aim of the present project is to detect biochemical alterations that can pinpoint specific pathogenic processes at early phases of AD, evaluated in the cerebrospinal fluid, that more closely reflect the pathogenic processes in the brain, and independently of whether an amyloid response was trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039563 | Pride
Alzheimer's disease  cerebral spinal fluid proteomics 
ProteomicsProteomic Analysis of Mouse Cerebral Cortex Following Experimental Ischemic Stroke: Identifying Novel Biomarkers of Damage and Repair
Stroke remains a major global health challenge due to its high mortality and significant socioeconomic burden. Despite advances in clinical management, effective diagnostic tools and therapeutic strategies remain limited. This study aimed to identify and expand the repertoire of biomarkers of damage...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-19 | PXD067155 | Pride
Magnetic resonance imaging Mouse cerebral cortex Proteomic analysis Middle cerebral artery occlusion Ischemic injury Gene ontology 
ProteomicsChronic haloperidol treatment leads to an imbalance of synaptic excitation and inhibition of D1-MSN neurons pointing to a slow remodelling process
Schizophrenia is a chronic mental illness that is among the world’s top twenty causes of years lost to disability according to the global burden of disease 2019 (10.1016/S0140-6736(20)30925-9). Positive symptoms, including hallucinations and delusions in schizophrenia, often improved with convention...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038471 | Pride
Msn Haloperidol Proteomics 
UnknownLISA Pathfinder Performance Confirmed in an Open-Loop Configuration: Results from the Free-Fall Actuation Mode.
Not available
S-EPMC7810161 | biostudies-literature
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.
Not available
S-EPMC12706683 | biostudies-literature
UnknownODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing.
Not available
S-EPMC7809782 | biostudies-literature
UnknownNeuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial.
Not available
S-EPMC7616346 | biostudies-literature
UnknownGuidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study.
Not available
S-EPMC11200283 | biostudies-literature
UnknownImpact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.
Not available
S-EPMC4809570 | biostudies-literature
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