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ProteomicsTAOK3 controls naïve T cell homeostasis
Genetic deletion or kinase inactivation of TAOK3 resulted in a profound, cell-intrinsic loss of naive CD8⁺ T cells. Despite enhanced sensitivity to TCR ligation and enhanced downstream signalling, proliferating CD8⁺ T cells did not survive in vitro and anti-viral CD8⁺ T cell immunity was compromised...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD077760 | Pride
Ste20 kinase Tcr signaling Naïve t cells Phospho-proteomics 
ProteomicsProteomic Profiling of Dysbiosis-Challenged Broilers: Blood Biomarkers for Intestinal Health
The intestinal microbiome forms dynamic ecosystem whose balanced composition and functioning are essential for maintaining overall gut health and well-being in living organisms. In broilers, dysbiosis disrupts the microbiota-host balance, often without obvious clinical symptoms but with intestinal i...
ORGANISM(S): Gallus gallus (Chicken) 
2025-07-14 | PXD056546 | Pride
Intestinal permeability Broiler chicken Proteomics Dysbiosis Gut health Blood biomarkers 
ProteomicsBlood Proteome profiling for protein biomarker discovery in Broilers
Analysis of the blood proteome allows identification of proteins related to changes upon certain physiological conditions. The pathophysiology of necrotic enteritis (NE) has been extensively studied. While intestinal changes have been very well documented, data addressing NE-induced alterations in t...
ORGANISM(S): Gallus gallus (Chicken) 
2025-05-07 | PXD061607 | Pride
Gallus gallus Gut health Necrotic enteritis Lc-msms Blood plasma biomarkers 
ProteomicsThe complexome contextualizes proteomics data to fingerprint biological states and highlight perturbed functional modules in disease
Proteins organize into functional assemblies that drive diverse biological activities. Leveraging a comprehensive dataset of manually curated annotations for the human protein complexome, we investigated biological perturbations at the protein complex level. Using proteomics and transcriptomics data...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD048352 | Pride
ProteomicsA simple peptide quantification approach for MS-based proteomics quality control
Despite its growing popularity and use, bottom-up proteomics remains a complex analytical methodology. Its general workflow consists of three main steps: sample preparation, liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and computational data analysis. Quality assessment of th...
ORGANISM(S): Homo sapiens (Human) 
2020-07-28 | PXD014524 | Pride
Method optimization Bottom-up proteomics Peptide quantitation Quality control 
ProteomicsBlood Proteome profiling for protein biomarker discovery in Broilers
Analysis of the blood proteome allows identification of proteins related to changes upon certain physiological conditions. The pathophysiology of necrotic enteritis (NE) has been extensively studied. While intestinal changes have been very well documented, data addressing NE-induced alterations in t...
ORGANISM(S): Gallus gallus (Chicken) 
2025-05-13 | PXD050473 | Pride
Proteomics Dia Gastrointestinal health Necrotic enteritis Broiler chicken Dda 
ProteomicsBlood Proteome profiling for protein biomarker discovery in Broilers
Analysis of the blood proteome allows identification of proteins related to changes upon certain physiological conditions. The pathophysiology of necrotic enteritis (NE) has been extensively studied. While intestinal changes have been very well documented, data addressing NE-induced alterations in t...
ORGANISM(S): Gallus gallus (Chicken) 
2025-05-13 | PXD050461 | Pride
Proteomics Dia Gastrointestinal health Necrotic enteritis Broiler chicken Dda 
ProteomicsDevelopment of PROTACs for in vivo AURKA degradation in neuroblastoma
Aurora Kinase A (AURKA) is a well-established oncogenic factor and potent drug target in neuroblastoma given its crucial role during mitosis, MYCN-stabilization, DNA damage repair and replication fork stability. We previously reported a highly potent, selective and fast-acting AURKA degrader, SK2188...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD061539 | Pride
Aurora kinase a Lc-msms Sk5527 Protacs 
ProteomicsWhole-genome transformation for industrial yeast strain development
tRNAs are encoded by a large gene family, usually with several isogenic tRNAs interacting with the same codon. Mutations in the anticodon region of other tRNAs can overcome specific tRNA deficiencies. Phylogenetic analysis suggests that such mutations have occurred in evolution, but the driving forc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024655 | Pride
Anticodon Thermotolerance Trna Yeast Whole-genome transformation 
ProteomicsGlobal profiling of testicular and epidydimal sperm proteomes: protein markers of sperm post-testicular maturation
Mammalian spermatogenesis involves a series of events during which germ cells differentiate into immature sperm cells. Following spermatogenesis in the seminiferous tubules, sperm undergo post-testicular maturation where they suffer extensive remodelling of their proteome culminating in the acquisit...
ORGANISM(S): Bos taurus (Bovine) 
2026-01-28 | PXD066938 | Pride
Proteomics Epididymal maturation Bull Spermatozoa 
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