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ProteomicsOncogenic and microenvironmental signals drive cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signalling and is characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using Mx-Cre;PTPN11D61Y mice, which reflect human JMML, we show that RAS pathway activat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055845 | Pride
Ptpn11 Bcl2 Jmml Apoptosis Bcl-xl Juvenile monocytic leukemia Mcl-1 Extrinsic and intrinsic shp2 signalling Shp2 
ProteomicsHead and neck squamous cell carcinoma-derived small extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor cells as well as modulation of a highly immunosuppressive tumor microen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060122 | Pride
Small extracellular vesicles  tissue factor Coagulation cascade Head and neck squamous cell carcinoma  platelet activation Cancer-associated thrombosis 
TranscriptomicsArabidopsis tissue atlas
We used state of the art mass spectrometry and RNA sequencing (RNA-Seq) to provide the first integrated proteomic, phosphoproteomic and transcriptomic atlas of Arabidopsis. For this we measured 30 different Arabidopsis tissues from adult plants, seedlings, callus and cell culture samples to an avera...
ORGANISM(S): Arabidopsis thaliana 
2020-01-10 | E-MTAB-7978 | biostudies-arrayexpress
UnknownDENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis.
Not available
S-EPMC5339766 | biostudies-literature
ProteomicsRebuilding core abscisic acid signaling pathways of Arabidopsis in yeast
The signaling pathway of the phytohormone abscisic acid (ABA) regulates responses towards abiotic stress such as drought and high osmotic conditions. The multitude of functionally redundant components involved in ABA signaling, poses a major challenge for elucidating the largely unresolved response ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Saccharomyces cerevisiae (Baker's yeast) 
2019-07-30 | PXD013669 | Pride
Arabidopsis Yeast Snrk2 phosphorylation Aba 
ProteomicsAnionic phospholipids connect barley ROP signaling with resistance and susceptibility to fungal cell entry
Rho-of-plant small GTPases (ROPs) are regulators of cell polar growth processes and of plant-pathogen interactions. The barley ROP protein RACB is involved in susceptibility towards infection by the barley powdery mildew fungus Blumeria hordei, but little is known about the cellular pathways that co...
ORGANISM(S): Blumeria hordei A6 Hordeum vulgare (Barley) 
2024-12-12 | PXD056811 | Pride
Blumeria Rho-of-plant small gtpase Barley 
ProteomicsExpression profiling of Arabidopsis leaf, flower and fruit development
With the quantitative profiling of consecutive tissue growth stages, we provide a global overview of expression changes of individual genes that play a role in dynamic cellular processes and developmental changes. We used tandem mass tag-based mass spectrometry and RNA sequencing to generate proteom...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-15 | PXD018814 | Pride
Proteomics Phospho Arabidopsis Development 
ProteomicsPosttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects. Two major pathways regulate G-protein activity: canonical switching of the nucle...
ORGANISM(S): Hordeum vulgare (Barley) 
2021-11-02 | PXD019273 | Pride
Rho-type g-protein Ubiquitination Phosphorylation Barley 
ProteomicsD6 PROTEIN KINASE plasma membrane polarity is dependent on a repeated CXX(X)P motif and serine phosphorylation
D6 PROTEIN KINASE (D6PK) is a polarly localized plasma membrane-associated kinase from Arabidopsis thaliana that activates polarly distributed PIN-FORMED (PIN) auxin transporters. D6PK traffics rapidly to and from the plasma membrane, independently from its PIN targets. D6PK plasma membrane associat...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-23 | PXD037885 | Pride
Arabidopsis D6 protein kinase Phosphorylation Polarity 
UnknownLinking post-translational modifications and protein turnover by site-resolved protein turnover profiling.
Not available
S-EPMC8748498 | biostudies-literature
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