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ProteomicsOncogenic and microenvironmental signals drive cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signalling and is characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using Mx-Cre;PTPN11D61Y mice, which reflect human JMML, we show that RAS pathway activat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055845 | Pride
Ptpn11 Bcl2 Jmml Apoptosis Bcl-xl Juvenile monocytic leukemia Mcl-1 Extrinsic and intrinsic shp2 signalling Shp2 
ProteomicsHead and neck squamous cell carcinoma-derived small extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor cells as well as modulation of a highly immunosuppressive tumor microen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060122 | Pride
Small extracellular vesicles  tissue factor Coagulation cascade Head and neck squamous cell carcinoma  platelet activation Cancer-associated thrombosis 
TranscriptomicsArabidopsis tissue atlas
We used state of the art mass spectrometry and RNA sequencing (RNA-Seq) to provide the first integrated proteomic, phosphoproteomic and transcriptomic atlas of Arabidopsis. For this we measured 30 different Arabidopsis tissues from adult plants, seedlings, callus and cell culture samples to an avera...
ORGANISM(S): Arabidopsis thaliana 
2020-01-10 | E-MTAB-7978 | biostudies-arrayexpress
ProteomicsRebuilding core abscisic acid signaling pathways of Arabidopsis in yeast
The signaling pathway of the phytohormone abscisic acid (ABA) regulates responses towards abiotic stress such as drought and high osmotic conditions. The multitude of functionally redundant components involved in ABA signaling, poses a major challenge for elucidating the largely unresolved response ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Saccharomyces cerevisiae (Baker's yeast) 
2019-07-30 | PXD013669 | Pride
Arabidopsis Yeast Snrk2 phosphorylation Aba 
ProteomicsExpression profiling of Arabidopsis leaf, flower and fruit development
With the quantitative profiling of consecutive tissue growth stages, we provide a global overview of expression changes of individual genes that play a role in dynamic cellular processes and developmental changes. We used tandem mass tag-based mass spectrometry and RNA sequencing to generate proteom...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-15 | PXD018814 | Pride
Proteomics Phospho Arabidopsis Development 
ProteomicsD6 PROTEIN KINASE plasma membrane polarity is dependent on a repeated CXX(X)P motif and serine phosphorylation
D6 PROTEIN KINASE (D6PK) is a polarly localized plasma membrane-associated kinase from Arabidopsis thaliana that activates polarly distributed PIN-FORMED (PIN) auxin transporters. D6PK traffics rapidly to and from the plasma membrane, independently from its PIN targets. D6PK plasma membrane associat...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-23 | PXD037885 | Pride
Arabidopsis D6 protein kinase Phosphorylation Polarity 
ProteomicsArabidopsis proteomic tissue atlas
Qualitative and quantitative atlas of the transcriptomes, proteomes and phosphoproteomes of 30 tissues of the model plant Arabidopsis. We describe how many genes were detected as proteins (>18,000), where they are expressed, in which approximate quantities (>6 logs dynamic range) and to what extent ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-01-10 | PXD013868 | Pride
Phosphoproteome Arabidopsis Proteome Tissue atlas 
ProteomicsLinking post-translational modifications and protein turnover by site-resolved protein turnover (SPOT) profiling
Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labelling and mass spectrometry to measure the turnover of >120,000 peptidoforms including >33,000 phosphorylated, acetylated, and ...
ORGANISM(S): Homo Sapiens 
2022-03-14 | PXD023234 | panorama
ProteomicsRebuilding core abscisic acid signaling pathways of Arabidopsis in yeast
The signaling pathway of the phytohormone abscisic acid (ABA) regulates responses towards abiotic stress such as drought and high osmotic conditions. The multitude of functionally redundant components involved in ABA signaling, poses a major challenge for elucidating the largely unresolved response ...
ORGANISM(S): Arabidopsis Thaliana Saccharomyces Cerevisiae 
PXD013849 | panorama
ProteomicsARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression
The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development of B cell malignancies. The classic form of follicu...
ORGANISM(S): Homo Sapiens 
PXD041408 | panorama
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