Sort   by:  
 Page size 
ProteomicsProteomic profiling of human colorectal adenocarcinoma Caco-2 cells in response to treatment with mesyl oligonucleotides targeting microRNAs miR-21, miR-155, and miR-17
Colorectal cancer (CRC) ranks among the most aggressive human malignancies and remains a leading cause of cancer mortality globally (Matsuda T. et al., Digestion, 2025). Despite advances in treatment, there is a critical need for novel therapeutic agents that combine high selectivity and minimal tox...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD069826 | Pride
Mesyl oligonucleotides Mir-21 Antisense oligonucleotides Antimirs Colorectal adenocarcinoma Microrna Mir-17 Mir-155 Proteomic profiling Caco-2 Lc-ms/ms 
UnknownMesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.
Not available
S-EPMC6347720 | biostudies-literature
UnknownMesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
Not available
S-EPMC7768764 | biostudies-literature
UnknownStructure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.
Not available
S-EPMC10944894 | biostudies-literature
UnknownReversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells.
Not available
S-EPMC12730878 | biostudies-literature
UnknownSingle Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy.
Not available
S-EPMC9496860 | biostudies-literature
UnknownBiological Performance and Molecular Mechanisms of Mesyl MicroRNA-Targeted Oligonucleotides in Colorectal Cancer Cells.
Not available
S-EPMC12692703 | biostudies-literature
UnknownTowards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Not available
S-EPMC8450106 | biostudies-literature
UnknownTargeted Inhibition of Oncogenic microRNAs miR-21, miR-17, and miR-155 Suppresses Tumor Growth and Modulates Immune Response in Colorectal Cancer.
Not available
S-EPMC12845401 | biostudies-literature
Sort   by:  
 Page size