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ProteomicsThe transcription factor TAL1 and the miR-17-92 cluster establish a regulatory loop
A network of gene regulatory factors such as transcription factors and microRNAs establish and maintain the gene expression pattern during hematopoiesis. In this network transcription factors regulate each other and are involved in regulatory loops with microRNAs.The microRNA cluster miR-17-92 is lo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018052 | Pride
Human Microrna Blood Tal1 Jurkat cells Mir-17-92 Hematopoiesis 
ProteomicsmiR-17-92/106b regulate beta cell mitotic checkpoint and insulin secretion
Adult beta cells in the pancreas are the sole source of insulin in our body. Beta cell loss or increased demand for insulin, impose metabolic challenges because adult beta cells are generally quiescent and infrequently re-enter the cell division cycle. miR-17-92/106b is a family of proto-oncogene mi...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-17 | PXD012610 | Pride
Mouse Lc-msms Mir-17-92/106b 
ProteomicsmiR-17-92 sustains lymphoma growth by fine-tuning MYC
The synergism between c-MYC and miR-17-19b, a truncated version of the miR-17-92 cluster, is well documented during tumor initiation. However, little is known about miR-17-19b function in established cancers. Here we investigate the role of miR-17-19b in c-MYC-driven lymphomas by integrating SILAC-b...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-06 | PXD002810 | Pride
Lc-msms Lymphoma Microrna Myc Mir-17-92 Chek2 
ProteomicsProteomic profiling of human colorectal adenocarcinoma Caco-2 cells in response to treatment with mesyl oligonucleotides targeting microRNAs miR-21, miR-155, and miR-17
Colorectal cancer (CRC) ranks among the most aggressive human malignancies and remains a leading cause of cancer mortality globally (Matsuda T. et al., Digestion, 2025). Despite advances in treatment, there is a critical need for novel therapeutic agents that combine high selectivity and minimal tox...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD069826 | Pride
Mesyl oligonucleotides Mir-21 Antisense oligonucleotides Antimirs Colorectal adenocarcinoma Microrna Mir-17 Mir-155 Proteomic profiling Caco-2 Lc-ms/ms 
TranscriptomicsGenome-wide prediction of genes targeted by titrated levels of miR-17~92
The miR-17-92 cluster targets mRNAs involved in distinct pathways which either promote or inhibit tumor progression. However, the cellular and molecular mechanisms underlying miR-17~92 cluster mediated pro- or anti- tumorigenic effects has not been studied. In this study, we found that inhibition of...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-55631 | biostudies-arrayexpress
TranscriptomicsExpression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells
During acute viral infections, effector CD8+ T cells differentiate into memory precursors or short-lived terminal effectors. miR-17-92a over-expression skews CD8+ effector cells to the terminal differentiation. We used microarray to identify the genes that are differentially expressed caused by miR-...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34217 | biostudies-arrayexpress
TranscriptomicsEffects on adult testis of Sertoli cell-specific ablation of miR-17-92 in mouse embryos
We induced specific deletion of miR-17-92 in Sertoli cells at the time of Amh expression in mouse embryos. We analyzed the effect of this deletion in the long term in adult testis. The transcriptome of mutant testis was consistently altered but do not produce a phenotype due to the testis homeostasi...
ORGANISM(S): Mus musculus 
2018-05-10 | E-MTAB-5914 | biostudies-arrayexpress
TranscriptomicsUsing AmpliSeq we have performed quantitative analysis of 20,803 genes in Negative control precursor-miR (NC-Pre-miR) and pre-miR-17 transfected Rheumatoid arthritis Synovial Fibroblasts (RASFs)
Purpose: The goals of this study are to determine the effect of microRNA-17 overexpression on 20,803 human genes in RASFs using Ion ProtonTM System platform. Human RASFs from two RA patients were transfected with pre-miR-17 or NC-pre-miR for 48 h and total RNA was prepared using miRNeasy kit (Qiagen...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-83930 | biostudies-arrayexpress
TranscriptomicsTemporal expression of miR-17-92a regulates effector and memory CD8+ T cell differentiation
This SuperSeries is composed of the following subset Series: GSE34216: miRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection GSE34217: Expression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34218 | biostudies-arrayexpress
GenomicsOverexpression of the miR-17-92 cluster in colorectal adenoma organoids induces a carcinoma-like genotype
Gain of chromosome arm 13q is one of the most prevalent DNA copy number alterations associated with colorectal adenoma-to-carcinoma progression. The oncogenic miR-17-92 cluster, located at 13q, was found to be overexpressed in colorectal cancer and in adenomas harboring 13q gain. However, to what ex...
EGAS00001005949 | EGA
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