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TranscriptomicsmiR-21 bone marrow derived eos
Bone marrow derived eosinophil culture from miR-21 wildtype and miR-21 deficient mice
ORGANISM(S): Mus musculus 
2013-05-01 | E-MEXP-3346 | biostudies-arrayexpress
ProteomicsProteomic profiling of human colorectal adenocarcinoma Caco-2 cells in response to treatment with mesyl oligonucleotides targeting microRNAs miR-21, miR-155, and miR-17
Colorectal cancer (CRC) ranks among the most aggressive human malignancies and remains a leading cause of cancer mortality globally (Matsuda T. et al., Digestion, 2025). Despite advances in treatment, there is a critical need for novel therapeutic agents that combine high selectivity and minimal tox...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD069826 | Pride
Mesyl oligonucleotides Mir-21 Antisense oligonucleotides Antimirs Colorectal adenocarcinoma Microrna Mir-17 Mir-155 Proteomic profiling Caco-2 Lc-ms/ms 
TranscriptomicsMiR-21 function in T-lymphocytes
T-lymphocyte activation is efficiently mimicked in vitro by treatment with anti CD3 / anti CD28 antibodies. We report miR-21 induction upon CD3/CD28 stimulation of primary T-lymphocytes. In order to assess the function of miR-21 in T-lymphocytes we interfered with miR-21 function by lentiviral trans...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-37213 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-21 targets in Jurkat cells by AGO2 immunoprecipitation
In order to identify miR-21 targets by a biochemical high-throughput method, we immunopurified RISC Complex and associated mRNAs in both control and miR-21 overexpressing Jurkat cells. Following transduction of miR-21 encoding construct (or a cognate control vector) in Jurkat cells, we used microarr...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-37212 | biostudies-arrayexpress
TranscriptomicsExperimental identification of apoptosis-associated miR-21 target genes in Jurkat T-cells using a high-throughput experimental approach
MiR-21 is an important suppressor of T-cell apoptosis that is also widely overexpressed in many types of cancers. The exact mechanisms related to the anti-apoptotic effect of miR-21 is not well understood. In this study, we applied AGO2 RNA Immunoprecipitation followed by gene expression profiling (...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-85116 | biostudies-arrayexpress
TranscriptomicsMiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer from never-smokers
Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are mo...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-14936 | biostudies-arrayexpress
TranscriptomicsmiR-21 OVA Lung
Lungs from miR-21+/+ and miR-21-/- mice sensitized with OVA/Alum and challenged with either saline or OVA.
ORGANISM(S): Mus musculus 
2011-08-25 | E-MEXP-3119 | biostudies-arrayexpress
GenomicsGene-editing of miR-21 to target glioma
Gene-editing of miR-21 to target glioma
PRJNA756036 | ENA
TranscriptomicsMiR-21 involves in cervical squamous cell tumorigenesis and regulates CCL20
MicroRNA 21 (miR-21) has been implicated in various aspects of carcinogenesis. However, the function and molecular mechanism of miR-21 in cervical squamous carcinoma has not been studied. Using TaqMan quantitative real-time PCR and Northern blot, we confirmed that miR-21 is significantly overexpress...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-29242 | biostudies-arrayexpress
TranscriptomicsMicroarray of K562 cell line after overexpression of miR-15a-5p or miR-21-5p.
The aim was to look for target genes of miR-15a-5p or miR-21-5p.
ORGANISM(S): Homo sapiens 
2021-02-11 | E-MTAB-8776 | biostudies-arrayexpress
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