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TranscriptomicsTranscription profiling of human primary effusion lymphoma cell lines reveals Kaposis sarcoma-associated herpesvirus encodes an ortholog of miR-155
MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate gene expression by binding to 3’UTRs of target mRNAs. Kaposi’s sarcoma-associated herpesvirus (KSHV), a virus linked to malignancies including primary effusion lymphoma (PEL), encodes 12 miRNA genes, but only a few regulat...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9264 | biostudies-arrayexpress
ProteomicsProteomic profiling of human colorectal adenocarcinoma Caco-2 cells in response to treatment with mesyl oligonucleotides targeting microRNAs miR-21, miR-155, and miR-17
Colorectal cancer (CRC) ranks among the most aggressive human malignancies and remains a leading cause of cancer mortality globally (Matsuda T. et al., Digestion, 2025). Despite advances in treatment, there is a critical need for novel therapeutic agents that combine high selectivity and minimal tox...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD069826 | Pride
Mesyl oligonucleotides Mir-21 Antisense oligonucleotides Antimirs Colorectal adenocarcinoma Microrna Mir-17 Mir-155 Proteomic profiling Caco-2 Lc-ms/ms 
TranscriptomicsA miR-155-ruled microRNA hierarchy in dendritic cell maturation and macrophage activation
MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in many cellular pathways. MiRNAs associate with members of the Argonaute (Ago) protein family and bind to partially complementary sequences on mRNAs and induce translational repression or mRNA decay. MiRNA expression can be cont...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-48404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of a mouse macrophage cell line TO investigating genes regulated BY mir-155
Mammalian microRNAs (miRNAs) are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion...
ORGANISM(S): Mus musculus 
2008-04-04 | E-GEOD-10467 | biostudies-arrayexpress
TranscriptomicsKidney toxicity in miR-155-/- mice
The development of nephrotoxicity limits the maximum achievable dosage and treatment intervals for cisplatin chemotherapy. Therefore, identifying mechanisms that regulate this toxicity could offer novel methods to optimize cisplatin delivery. MicroRNAs are capable of regulating many different genes,...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-57292 | biostudies-arrayexpress
TranscriptomicsmiR-155 plays a crucial role in ALS and is an immune therapeutic target [RNA-Seq]
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-52946 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting
This SuperSeries is composed of the following subset Series: GSE41241: Transcriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting [mRNA expression data] GSE41285: Transcriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting [CLIP-seq data...
ORGANISM(S): Mus musculus 
2012-11-09 | E-GEOD-41288 | biostudies-arrayexpress
ProteomicsCirculating Tenascin-C/-miR-155-5p identified as promising prognostic candidates of intervertebral disc herniation
Intervertebral disc (IVD) herniation is a complex and multifactorial condition with challenging diagnosis and limited therapeutic options, highlighting the need for reliable biomarkers to improve clinical decision-making. The aim of this study was to identify circulating prognostic biomarkers of IVD...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-02 | PXD071649 | Pride
Disc herniation Proteomics Mirna Intervertebral disc Circulating biomarkers 
TranscriptomicsMiR-155 is protective of dietary non-alcoholic hepatosteatosis
We used microarrays to characterize the gene expression changes in liver caused by high fat diet feeding to C57BL/6 WT and miR-155-/- mice. Livers were collected from male mice at 24 weeks of age for RNA extraction and hybridization on Affymetrix mouse gene 1.0 ST array . We extracted RNA from 3 ani...
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3932 | biostudies-arrayexpress
TranscriptomicsmiR-155 KO in human dendritic cells
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-deri...
ORGANISM(S): Homo sapiens 
2009-03-04 | E-GEOD-13296 | biostudies-arrayexpress
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