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TranscriptomicsZinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MTF1; therefore, the aim of this study was to gain a more complete understanding of the MTF-1 regulated zinc-responsive component of the transcriptome. A targeted siRNA was used to deplete MTF1 express...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-GEOD-76510 | biostudies-arrayexpress
TranscriptomicsGene expression profile of isolated splenic NK cells from mice treated with ptaquiloside and/or selenium
To better understand the immunosuppressor mechanism of ptaquiloside in splenic NK cells and the reversion of this effect by selenium, we have employed whole genome microarray expression profile to identify genes associated with immunosuppression. Among 89 genes induced by ptaquiloside treatment in s...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-30629 | biostudies-arrayexpress
TranscriptomicsDrivers of metallothionein-mediated detoxification of cadmium in C.elegans
Cadmium is toxic and intricate pathways linked to metallothioneins (MT) drive the detoxification process. Whist the mechanisms are well understood in mammalian systems, detailed knowledge is still elusive in invertebrates (which notably differ to mammalian systems). The model nematode Caenorhabditi...
ORGANISM(S): Caenorhabditis elegans 
2014-06-01 | E-GEOD-29951 | biostudies-arrayexpress
TranscriptomicsIncreased metallothionein expression reflects steroid resistance in renal allograft recipients.
Steroid-refractory acute rejection is a risk factor for inferior renal allograft outcome. We aimed to gain insight into the mechanisms underlying steroid resistance by identifying novel molecular markers of steroid-refractory acute rejection. Eighty-three kidney transplant recipients (1995-2005), wh...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-47097 | biostudies-arrayexpress
ProteomicsMetallothionein-like peptides of Russula atropurpurea
The Zn complexes and their peptide ligands were characterized using chromatography, electrophoresis after the fluorescent labeling of cysteine residues, and tandem mass spectrometry.
ORGANISM(S): Russula atropurpurea 
2014-07-16 | PXD001073 | Pride
Lc-msms Metallothionein Russula atropurpurea 
ProteomicsTop down analysis of human MT2 modification by ajoen and allicine
Garlic (Allium sativum) is a widely used culinary ingredient of multiple cuisines. Once disintegrated garlic cloves release volatile sulfur compounds, the so-called garlic organosulfur compounds (GOSC). The most famous of these are allicin and ajoen, known for their antimicrobial properties. These c...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD059722 | Pride
Metallothionein mt2 allicin ajoen gosc allium sativum garlic organosulfur compounds top down modification 
GenomicsMetallothionein 1 Regulates Growth and Survival of DNMT3A NPM1-Mutant Acute Myeloid Leukemia
Metallothionein 1 Regulates Growth and Survival of DNMT3A NPM1-Mutant Acute Myeloid Leukemia
PRJNA1164831 | ENA
GenomicsChIP-seq of E2f, Max, Myb and Myc in Drosophila melanogaster S2 cells for mapping their genome-wide binding sites
ChIP-seq for the strongest cell cycle regulator transcription factors in Drosophila Melanogaster S2 cells. These assays have been used to validate the direct transcriptional targets of the same transcription factors investigated in RNA-seq (E-MTAB-1364) and Affymetrix microarray experiments (E-MTAB-...
ORGANISM(S): Drosophila melanogaster 
2013-08-01 | E-MTAB-1648 | biostudies-arrayexpress
UnknownMetallothionein expression in feline injection site fibrosarcomas.
Not available
S-EPMC9912506 | biostudies-literature
GenomicsMetallothionein 1 (Mt1) Regulates Growth and Survival of DNMT3A NPM1-Mutant Acute Myeloid Leukemia
Metallothionein 1 (Mt1) Regulates Growth and Survival of DNMT3A NPM1-Mutant Acute Myeloid Leukemia
PRJNA1090929 | ENA
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