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ProteomicsAn OMICS perspective on N-terminal Methionine Excision
Excision of the N-terminal initiator methionine (iMet) from nascent peptide chains is an essential and omnipresent protein modification carried out by Methionine aminopetidases (MetAPs) and accounting for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicated in pr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-10 | PXD006638 | Pride
Metap Metap1 Shotgun N-terminal proteomics Imet excision 
TranscriptomicsOMICS assisted N-terminal proteoform and protein expression profiling upon methionine aminopeptidase 1 (MetAP1) deletion
Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an essential and omnipresent protein modification carried out by methionine aminopeptidases (MetAPs) that accounts for a major source of N-terminal proteoform diversity. While MetAP2 is known to be implicat...
ORGANISM(S): Homo sapiens 
2018-01-12 | GSE103405 | GEO
UnknownVenous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.
Not available
S-EPMC11747776 | biostudies-literature
UnknownMETAP1 mutation is a novel candidate for autosomal recessive intellectual disability.
Not available
S-EPMC7785574 | biostudies-literature
UnknownOmics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion.
Not available
S-EPMC5880116 | biostudies-literature
UnknownMechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD.
Not available
S-EPMC12716425 | biostudies-literature
UnknownMetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.
Not available
S-EPMC5325365 | biostudies-literature
GenomicsHomo sapiens
OMICS assisted N-terminal proteoform and protein expression profiling upon methionine aminopeptidase 1 (MetAP1) deletion
PRJNA401719 | ENA
ProteomicsDiscovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling
Cisplatin is a widely-used cancer metallodrug which induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was fo...
ORGANISM(S): Homo Sapiens 
2023-07-08 | PXD043629 |
UnknownElucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Not available
S-EPMC1838721 | biostudies-literature
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